Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPTIC_PRUNING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | modulates | gene | 0.90 |
| C4B | mediates | gene | 0.90 |
| complement_cascade | activates | pathway | 0.85 |
| C1Q | regulates | protein | 0.70 |
| C1QA | mediates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 20 hypotheses Top: 0.651
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Network pharmacology analysis of QTJD active compounds and pathways | exploratory | Mycoplasma pneumoniae pneumoni | 0.900 | 0.00 | computational network analysis | proposed | N/A |
| C1q neutralization experiment | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| scRNA-seq analysis of human atherosclerotic plaques | exploratory | Atherosclerosis | 0.900 | 0.00 | human atherosclerotic plaque s | proposed | N/A |
| Sevoflurane-induced neurotoxicity (SIN) model in rats | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| Machine learning-based identification of C1Q hub genes | exploratory | Atherosclerosis | 0.900 | 0.00 | Human bulk RNA sequencing data | proposed | N/A |
| Transcriptomic profiling and differential expression analysis | exploratory | Alzheimer's disease | 0.900 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| Gene expression validation in apoE-/- mice | validation | Atherosclerosis | 0.850 | 0.00 | apoE-/- mice | proposed | N/A |
| ox-LDL treatment of RAW264.7 macrophages | exploratory | Atherosclerosis | 0.850 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| bEV-mediated synaptic pruning via C1q-C3 pathway | exploratory | Alzheimer's disease | 0.850 | 0.00 | microglia and synapses (in viv | proposed | N/A |
| Validation of hub genes in ox-LDL treated RAW264.7 macrophages | exploratory | Atherosclerosis | 0.800 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| Validation of hub genes in apoE-/- atherosclerotic mice | validation | Atherosclerosis | 0.800 | 0.00 | apoE-/- mice | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274] | Xu F, Han L, Wang Y, Deng D, Ding Y, Zha | BMC Med | 2023 | 2 |
| Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] | De Schepper S, Ge JZ, Sierksma A, Crowle | Nat Neurosci | 2023 | 2 |
| Young adult microglial deletion of C1q reduces engulfment of synapses and preven [PMID:41000995] | Petrisko TJ, Chu SH, Gomez-Arboledas A, | bioRxiv : the preprint server | 2025 | 1 |
| Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-med [PMID:40731189] | Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, | Alzheimer's & dementia : the j | 2025 | 1 |
| Trigeminal neuralgia. [PMID:38816415] | Ashina S, Robertson CE, Srikiatkhachorn | Nature reviews. Disease primer | 2024 | 1 |
| Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455] | Cornell J, Salinas S, Huang HY, Zhou M | Neural Regen Res | 2022 | 1 |
| The Role of Complement in Synaptic Pruning and Neurodegeneration. [PMID:34595138] | Gomez-Arboledas A, Acharya MM, Tenner AJ | ImmunoTargets and therapy | 2021 | 1 |
| Early complement genes are associated with visual system degeneration in multipl [PMID:31289819] | Fitzgerald KC, Kim K, Smith MD, Aston SA | Brain | 2019 | 1 |
| Opioid Receptors. [PMID:26332001] | Stein C | Annual review of medicine | 2016 | 1 |
| Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an [PMID:41396874] | Unknown | Brain : a journal of neurology | 2026 | 0 |
| Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964] | Righes Marafiga J, Vu T, Bowlus J, Barab | Progress in neurobiology | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | Geroscience | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | GeroScience | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542] | Ahmed S, Bowers C, Munoz-Martin J, Jamwa | Brain, behavior, and immunity | 2026 | 0 |
| Sex-Specific Molecular Architecture of Microglia-Mediated Neuronal Pruning Acros [PMID:41324815] | Sanfilippo C, Castrogiovanni P, Imbesi R | Molecular neurobiology | 2025 | 0 |
| Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into [PMID:40972649] | Griggs M, Daylor V, Petrucci T, Weintrau | ImmunoHorizons | 2025 | 0 |
| C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of [PMID:38278523] | ["Angela Gomez-Arboledas", "Maria I Fons | Alzheimer's & dementia : t | 2024 | 0 |
| The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007] | Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ, | Journal of neuroinflammation | 2024 | 0 |
| Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic [PMID:37905877] | ["Huo Anran", "Wang Jiali", "Li Qi", "Li | Neural regeneration research | 2024 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning SYNAPTIC_PRUNING in their description or question text
Score: 0.612 · alzheimers · 2026-04-04
# Synaptic Pruning Precision Therapy: Targeting Complement and Chemokine Signaling to Preserve Neuronal Connectivity
Score: 0.535 · connectomics · 2026-04-25
Microglial TREM2 Activation to Enhance Synaptic Pruning Regulation
Score: 0.521 · neurodegeneration · 2026-04-14
## Mechanistic Overview TREM2 Agonism to Redirect Microglia from Synaptic Pruning to OPTN-Deficient Neuron Protection st
Score: 0.380 · perioperative-neurocognitive-disorders · 2026-04-26
Prolonged anesthesia triggers complement activation (C1q/C3) that drives microglia-mediated synaptic elimination with pr
Score: 0.380 · connectomics · 2026-04-27
This hypothesis proposes that targeted modulation of microglial synaptic pruning activity can restore optimal functional
Score: 0.380 · synaptic-biology · 2026-04-27
This hypothesis proposes that activity-dependent CREB signaling creates spatially distinct complement vulnerability maps
Score: 0.354 · connectomics · 2026-04-26
Astrocytes play a critical role in synaptic pruning and maintenance of neural circuits through complement-mediated elimi
Score: 0.000 · unknown disease · 2026-04-28
Microglial activation and synaptic pruning genes may be differentially regulated across populations, with SEA-AD cohorts