protein

SYNAPTOTAGMIN-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTOTAGMIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections
1Hypotheses
1Analyses
1Outgoing
0Incoming
0Experiments
2Debates

Summary

SYT1: calcium sensor for fast synchronous neurotransmitter release, C2 domain structure, AD/PD dysfunction, epilepsy mutations

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🔬 Protein Info
Gene SymbolSYNAPTOTAGMIN
FunctionVesicle pool dynamics: SYT1 dysfunction impairs synaptic vesicle recycling in dopaminergic neurons
Molecular Weight47.5 kDa
Amino Acids421 aa
GeneCardsSYNAPTOTAGMIN
Human Protein AtlasSYNAPTOTAGMIN
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Synaptotagmin-1 Protein

redirect · 654 words

Pathway Diagram

graph TD
    A["Gene expression"] --> B["SYNAPTOTAGMIN 1"]
    B --> C["Protein folding and
quality control"] B --> D["Cellular signaling"] C --> E["Proteostasis"] D --> F["Neurotoxicity"] E --> G["Disease outcome"] F --> G classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0 classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0 classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0 class B protein class G disease

Outgoing (1)

TargetRelationTypeStr
tau releasemodulatesprocess0.70

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs 0.652 neurodegeneration What are the specific PTM changes in syn

Mentioning Analyses (1)

Scientific analyses that reference this entity

Trans-synaptic tau spreading and propagation mechanisms in AD

neuroscience | 2026-04-04 | 9 hypotheses Top: 0.822

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Debate: Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activat

closed · Rounds: 4 · Score: 0.34 · 2026-04-27

Tau pathology spreads through synaptically connected brain regions in Alzheimer

closed · Rounds: 4 · Score: 0.78 · 2026-04-22

Related Research

Hypotheses and analyses mentioning SYNAPTOTAGMIN-1 in their description or question text

No additional research found