Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPTOTAGMIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYT1: calcium sensor for fast synchronous neurotransmitter release, C2 domain structure, AD/PD dysfunction, epilepsy mutations
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| Gene Symbol | SYNAPTOTAGMIN |
| Function | Vesicle pool dynamics: SYT1 dysfunction impairs synaptic vesicle recycling in dopaminergic neurons |
| Molecular Weight | 47.5 kDa |
| Amino Acids | 421 aa |
| GeneCards | SYNAPTOTAGMIN |
| Human Protein Atlas | SYNAPTOTAGMIN |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Gene expression"] --> B["SYNAPTOTAGMIN 1"]
B --> C["Protein folding and
quality control"]
B --> D["Cellular signaling"]
C --> E["Proteostasis"]
D --> F["Neurotoxicity"]
E --> G["Disease outcome"]
F --> G
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class B protein
class G disease| Target | Relation | Type | Str |
|---|---|---|---|
| tau release | modulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs | 0.652 | neurodegeneration | What are the specific PTM changes in syn |
Scientific analyses that reference this entity
neuroscience | 2026-04-04 | 9 hypotheses Top: 0.822
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.34 · 2026-04-27
closed · Rounds: 4 · Score: 0.78 · 2026-04-22
Hypotheses and analyses mentioning SYNAPTOTAGMIN-1 in their description or question text
No additional research found