Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Shikonin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Cell Proliferation | inhibits | process | 0.95 |
| AMPK/mTOR/ULK-1 Signaling Pathway | modulates | pathway | 0.95 |
| Apoptosis | associated_with | process | 0.95 |
| Autophagy | associated_with | process | 0.95 |
| Ampk/Mtor/Ulk1 | modulates | pathway | 0.90 |
| Fibroblast-Like Synoviocytes | targets | cell_type | 0.90 |
| ESM1-PKM2 interaction | inhibits | process | 0.90 |
| Rheumatoid Arthritis | treats | disease | 0.90 |
| ULK1 | activates | protein | 0.85 |
| rheumatoid arthritis | treats | disease | 0.85 |
| PKM2 | inhibits | protein | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Lithospermum Erythrorhizon | interacts_with | compound | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||