protein

PKM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

454Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for PKM2 Protein

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🔬 Protein Info

Gene Symbol	PKM2
Function	Pkm2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Primary Expression	Hypothalamus, Thalamus
Subcellular Localization	\| Cytoplasm, Nucleus ! Protein Family \| PKM family </div> ## Overview PKM2 Pro
Molecular Weight	57.9 kDa
Pathways	Glucose Metabolism
GeneCards	PKM2
Human Protein Atlas	PKM2
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, CHEMORESISTANCE, Glioblastoma, Glioma
Known Drugs/Compounds	circFRMD4A, Shikonin, Circfrmd4A, rapamycin, PKM2-IN-1
Interactions	AND, SIRT1, PARKINSON'S DISEASE, FRMD4A, P53, RNA
KG Connections	454 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PKM2("PKM2")
    GLYCOLYSIS["GLYCOLYSIS"]
    PKM2 -->|"involved_in"| GLYCOLYSIS
    PINK1("PINK1")
    PINK1 -->|"phosphorylates"| PKM2
    circFRMD4A["circFRMD4A"]
    circFRMD4A -->|"inhibits"| PKM2
    NEURODEGENERATION["NEURODEGENERATION"]
    PKM2 -->|"therapeutic_target"| NEURODEGENERATION
    PI3K_Akt_Pathway(["PI3K/Akt Pathway"])
    PI3K_Akt_Pathway -->|"phosphorylates"| PKM2
    PRMT1["PRMT1"]
    PRMT1 -->|"phosphorylates"| PKM2
    AKT1("AKT1")
    AKT1 -->|"phosphorylates"| PKM2
    circFRMD4A -->|"interacts_with"| PKM2
    AKT("AKT")
    AKT -->|"phosphorylates"| PKM2
    energy_production["energy production"]
    PKM2 -->|"regulates"| energy_production
    PIN1("PIN1")
    PKM2 -->|"binds"| PIN1
    ERK2("ERK2")
    ERK2 -->|"phosphorylates"| PKM2
    DLAT["DLAT"]
    DLAT -->|"interacts_with"| PKM2
    Akt("Akt")
    Akt -->|"regulates"| PKM2
    DRD2["DRD2"]
    DRD2 -->|"regulates"| PKM2

Outgoing (261)

Target	Relation	Type	Str
GLYCOLYSIS	involved_in	entity	0.95
Parkinson'S Disease	associated_with	disease	0.92
NEURODEGENERATION	therapeutic_target	entity	0.90
STAT3	phosphorylates	protein	0.90
Lactate Production	mediates	process	0.90
Lactate Production	regulates	process	0.90
Lactate	associated_with	compound	0.90
Lactate Production	promotes	process	0.90
Parkinson'S Disease	contributes_to	disease	0.90
Parkinson'S Disease	therapeutic_target	disease	0.90
NRF2 Promoter	binds	mechanism	0.90
Parkinson's disease	worsens	disease	0.90
aerobic glycolysis	involved_in	pathway	0.90
Parkinsonism	causes	phenotype	0.88
energy production	regulates	process	0.87
PIN1	binds	protein	0.80
Wnt signaling	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
SIRT1	activates	gene	0.70
MICROGLIA	causes	cell_type	0.70
MICROGLIA	regulates	cell_type	0.70
Glucose Metabolism	inhibits	process	0.70
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Ataxia	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	methylates	disease	0.65
Cancer	methylates	disease	0.65
Als	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Als	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Parkinson	activates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Aging	regulates	disease	0.65
LACTATE	causes	phenotype	0.65

Incoming (193)

Source	Relation	Type	Str
SIRT1	interacts_with	protein	0.95
SIRT1	associated_with	protein	0.95
Circfrmd4A	interacts_with	compound	0.95
Circfrmd4A	inhibits	compound	0.95
PRMT1	associated_with	protein	0.95
PINK1	phosphorylates	protein	0.93
circFRMD4A	inhibits	compound	0.92
PRMT1	phosphorylates	entity	0.90
circFRMD4A	interacts_with	compound	0.90
ESM1	interacts_with	protein	0.90
SUMO1	modulates	protein	0.90
PSMD14	deubiquitinating	protein	0.90
Pi3K/Akt Pathway	phosphorylates	pathway	0.90
PI3K/AKT	phosphorylates	pathway	0.90
PRMT1	methylates	protein	0.90
UBA2	modulates	protein	0.85
Shikonin	inhibits	drug	0.85
PKM2-IN-1	inhibits	drug	0.85
ERK2	phosphorylates	protein	0.80
DLAT	interacts_with	gene	0.80
MYC	regulates	gene	0.75
PFKFB3	activates	gene	0.70
SIRT1	modifies	gene	0.70
P53	upstream_of	protein	0.65
DRD2	regulates	gene	0.60
HDAC3	interacts_with	protein	0.60
APOPTOSIS	inhibits	gene	0.60
PFKFB3	inhibits	gene	0.60
BRAIN INJURY	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
IFN	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
SPR	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
IFN-Γ	inhibits	gene	0.60
LDHA	inhibits	gene	0.60
HK2	inhibits	gene	0.60
AMPK	expressed_in	gene	0.60
SLC16A3	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
P21	activates	gene	0.60
ATM	activates	gene	0.60
ROS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
DNA	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
EWSR1	activates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PKM2

Understanding Entity Pages

Summary

Wiki Pages (20)

Physical Therapy and Rehabilitation for Atypical Parkinsonism

Physical Therapy and Rehabilitation for Atypical Parkinsonism

sirtuin-dysfunction-parkinsons

PKM2 Metabolic Dysregulation in Alzheimer's Disease

HDAC10 Gene

Wearable Sensors and Digital Biomarkers for Atypical Parkinsonism (CBS/PSP)

stem-cell-therapy-parkinsonism

DLAT Gene

ERK2 Protein

Microglial Metabolic Reprogramming

Metabolic Dysfunction and Insulin Signaling Impairment Pathway

SIRT5 Protein - Mitochondrial Desuccinylase

Glycolysis Metabolism in Neurodegeneration

Automated Imaging Differentiation for Parkinsonism (AIDP)

HNRNPA1 - Heterogeneous Nuclear Ribonucleoprotein A1

ERK2 (MAPK1)

PGK1 Gene

PKM2 Protein