Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIRTUINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SIRTUINS |
| Summary | SIRT1 and SIRT2 roles in AD, PD, and ALS |
| Key Genes/Proteins | HISTONE_DEACETYLASE |
| Related Diseases | Cardiovascular Disease, DISEASE, APOPTOSIS, CELLULAR_SENESCENCE, OXIDATIVE_STRESS |
| Related Pathways | CELLULAR_METABOLISM |
Knowledge base pages for this entity
graph TD
SIRTUINS["SIRTUINS"]
SIRTUINS -->|"catalyzes"| Histone_Deacetylation["Histone Deacetylation"]
SIRTUINS -->|"modulates"| Ageing["Ageing"]
SIRTUINS -->|"involved_in"| Cardiovascular_Disease["Cardiovascular Disease"]
SIRTUINS -->|"regulates"| Cellular_Metabolism["Cellular Metabolism"]
SIRTUINS -->|"modulates"| DNA_Damage["DNA Damage"]
SIRTUINS -->|"encodes"| HISTONE_DEACETYLASE["HISTONE_DEACETYLASE"]
Nad_["Nad+"] -->|"regulates"| SIRTUINS
TULP3["TULP3"] -->|"activates"| SIRTUINS
NAD["NAD"] -->|"interacts"| SIRTUINS| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular Disease | involved_in | disease | 0.90 |
| Cellular Metabolism | regulates | process | 0.85 |
| DNA Damage | modulates | process | 0.80 |
| AGING | regulates | process | 0.80 |
| DISEASE | implicated_in | disease | 0.80 |
| HISTONE_DEACETYLASE | encodes | protein | 0.72 |
| APOPTOSIS | regulates | phenotype | 0.72 |
| CELLULAR_SENESCENCE | regulates | phenotype | 0.64 |
| OXIDATIVE_STRESS | regulates | phenotype | 0.64 |
| DNA_DAMAGE | regulates | phenotype | 0.64 |
| CELLULAR_METABOLISM | regulates | pathway | 0.64 |
| CARDIOVASCULAR_DISEASE | associated_with | disease | 0.64 |
| CARDIOVASCULAR_SYSTEM | expressed_in | cell_type | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TULP3 | activates | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||