Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| TERT | activates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| GWAS of plasma NfL in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| GWAS of plasma pTau217 in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| Dairy intake and dementia risk in Malmö Diet and Cancer cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Swedish community-based adults | proposed | N/A |
| GWAS of plasma pTau181 in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| GWAS of plasma GFAP in East Asian cohort | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients - East Asian co | proposed | N/A |
| KEEPS Continuation: Long-term effects of menopausal hormone therapy on | clinical | Alzheimer's disease | 0.950 | 0.00 | recently menopausal women with | proposed | N/A |
| GWAS of composite biomarker score | exploratory | Alzheimer's disease | 0.900 | 0.00 | human patients - East Asian co | proposed | N/A |
| RBG treatment in ApoE-/- atherosclerosis mouse model | validation | atherosclerosis | 0.900 | 0.00 | ApoE-/- mice | proposed | N/A |
| s:** - Biochemical binding assays measuring PROTAC selectivity for APO | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Validate Mitochondria-Lysosome Contact Site Dysfunction in PD | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| MLCS Quantification in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Lactate accumulation drives hepatocellular carcinoma metastasis through facilita [PMID:40120799] | Jiang C, He X, Chen X, Huang J, Liu Y, Z | Cancer Lett | 2025 | 1 |
| Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685] | Litvinchuk A, Suh JH, Guo JL, Lin K, Dav | Neuron | 2024 | 1 |
| The cell biology of APOE in the brain. [PMID:37805344] | Windham IA, Cohen S | Trends Cell Biol | 2024 | 1 |
| The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317] | Maxine R Nelson, Peng Liu, Ayushi Agrawa | Nature neuroscience | 2023 | 1 |
| TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signa [PMID:32972302] | Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Z | Autophagy | 2021 | 1 |
| Role of the endolysosomal pathway and exosome release in tau propagation. [PMID:33582164] | Yan M, Zheng T | Neurochem Int | 2021 | 1 |
| APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485] | Serrano-Pozo A, Das S, Hyman BT | Lancet Neurol | 2021 | 1 |
| Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216] | Banik SM, Pedram K, Wisnovsky S, Ahn G, | Nature | 2020 | 1 |
| Rab7a and Mitophagosome Formation. [PMID:30857122] | Tan EHN, Tang BL | Cells | 2019 | 1 |
| Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456] | Long JM, Holtzman DM | Cell | 2019 | 1 |
| Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008] | Yamazaki Y, Zhao N, Caulfield TR, Liu CC | Nat Rev Neurol | 2019 | 1 |
| Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188] | Cetindag AC, Schipke CG, Esselmann H, Kr | The journal of prevention of A | 2026 | 0 |
| Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635] | Thedim M, Hu J, Maher M, Wiener-Kronish | Br J Anaesth | 2026 | 0 |
| Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639] | Bae H, Song Z, Ali A, Sasaki T, Tesi N e | Geroscience | 2026 | 0 |
| Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401] | Stern A, Linial M | Geroscience | 2026 | 0 |
| Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963] | Zhu L, Du L, Wu J, Ding D, Wang J et al. | J Invest Dermatol | 2026 | 0 |
| Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204] | Sang Y, Cao Y, Li S, Quan Y, Wang S et a | Biomaterials | 2026 | 0 |
| Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196] | Lin Z, Xiong J, Zhang F, Zhang H, Zhu M | Mol Ther | 2026 | 0 |
| Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227] | Samudra N, Vemuri M, Weitlauf J | Curr Opin Obstet Gynecol | 2026 | 0 |
| YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA [PMID:41702019] | Chai J, Han L, Mo D, Bai Y, Yang Y et al | Redox Biol | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TAC in their description or question text
Score: 0.698 · neuroimmunology · 2026-04-15
## Mechanistic Overview Granzyme B Inhibition with Serpina3n to Preserve Axonal Integrity Against Cytotoxic Attack start
Score: 0.668 · neurodegeneration · 2026-04-02
## Mechanistic Overview Mitochondrial-Lysosomal Contact Site Engineering starts from the claim that modulating RAB7A wit
Score: 0.596 · alzheimers · 2026-04-07
## Mechanistic Overview Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibition and block tau
Score: 0.564 · alzheimers · 2026-04-20
## Mechanistic Overview Closed-loop tACS targeting EC-II somatostatin interneurons to restore dendritic integration and
Score: 0.530 · neurodegeneration · 2026-04-30
Altered mitochondria-associated membranes may disrupt calcium transfer, lipid synthesis, ROS handling, and apoptotic thr
Score: 0.473 · neurodegeneration · 2026-04-21
## Mechanistic Overview Cerebral VSMC foam cells induce pericyte detachment via PDGF-BB/VEGF imbalance, impairing neurov
Score: 0.455 · neurodegeneration · 2026-04-27
Target VDAC1-GRP75-IP3R1 complex to restore mitochondrial-ER communication and metabolic flexibility by addressing funda
Score: 0.408 · neurodegeneration · 2026-04-25
NOT RECOMMENDED. Critical safety contraindications: PU.1 knockout is embryonic lethal in mice; PU.1 haploinsufficiency i
Score: 0.342 · neurodegeneration · 2026-04-26
A longitudinal biomarker panel centered on ATAC-seq accessibility can distinguish harmful mechanisms from protective ada
Score: 0.327 · neurodegeneration · 2026-04-26
A longitudinal biomarker panel centered on ATAC-seq accessibility can distinguish harmful mechanisms from protective ada
Score: 0.320 · neurodegeneration · 2026-04-25
Healthy astrocytes produce prostaglandin I2 (prostacyclin), which signals via IP receptor on motor neurons, elevating cA
Score: 0.000 · unknown disease · 2026-04-28
Targeting disrupted VDAC1-LAMP1 interactions to restore calcium homeostasis and ATP supply to lysosomes Debate provenan