gene

TERT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TERT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

550Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Telomerase Reverse Transcriptase - catalytic subunit of telomerase with roles in cellular senescence, mitochondrial function, and neurodegeneration

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🧬 Gene Info

Gene Symbol	TERT
Full Name	Telomerase Reverse Transcriptase
Chromosome	5p15.33
Function	dyskerin (DKC1): Stabilizes the complex
Primary Expression	hippocampal subgranular zone (SGZ)
Molecular Weight	127 kDa
Amino Acids	1132 aa
Exons	16
Pathways	Telomere Dysfunction
UniProt ID	[O14748](https://www.uniprot.org/uniprot/O14748)
Ensembl ID	ENSG00000164362
OMIM	607409
GeneCards	TERT
Human Protein Atlas	TERT
Associated Diseases	AD, ALI, ALS, AMI, Cancer
Known Drugs/Compounds	TAC
Interactions	GJA1, ACVR2A, CTNNB1, TP53, NRF2, KEAP1
KG Connections	550 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TERT["TERT"] -->|"Promotes"| telomere_synthesis["telomere synthesis"]
    TERT["TERT"] -->|"Prevents"| cellular_senescence["cellular senescence"]
    TERT["TERT"] -->|"Modulates"| aging["aging"]
    TERT["TERT"] -->|"Therapeutic Target"| Cancer["Cancer"]
    TERT["TERT"] -->|"Therapeutic Target"| Carcinoma["Carcinoma"]
    TERT["TERT"] -->|"Therapeutic Target"| Ms["Ms"]
    TERT["TERT"] -->|"Therapeutic Target"| Als["Als"]
    TERT["TERT"] -->|"Biomarker For"| Neurodegeneration["Neurodegeneration"]
    TAC["TAC"] -->|"Activates"| TERT["TERT"]
    MEK_ERK_AP_1["MEK/ERK/AP-1"] -->|"Regulates"| TERT["TERT"]
    IDH1["IDH1"] -->|"Therapeutic Target"| TERT["TERT"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| TERT["TERT"]
    MDM4["MDM4"] -->|"Therapeutic Target"| TERT["TERT"]
    style TERT fill:#8d4900,color:#e0e0e0
    style telomere_synthesis fill:#1b5e20,color:#e0e0e0
    style cellular_senescence fill:#1b5e20,color:#e0e0e0
    style aging fill:#1b5e20,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style TAC fill:#00838f,color:#e0e0e0
    style MEK_ERK_AP_1 fill:#9C27B0,color:#e0e0e0
    style IDH1 fill:#8d4900,color:#e0e0e0
    style VEGFA fill:#8d4900,color:#e0e0e0
    style MDM4 fill:#8d4900,color:#e0e0e0

Outgoing (345)

Target	Relation	Type	Str
Telomere Dysfunction	causes	mechanism	0.95
Hepatocellular Carcinoma	biomarker_for	disease	0.90
BRAIN TUMOURS	associated_with	entity	0.85
Telomere Dysfunction	regulates	mechanism	0.85
Telomere Maintenance	involved_in	process	0.85
Tumor	activates	disease	0.85
MAPK1	activates	gene	0.80
Telomere Dysfunction	involved_in	process	0.80
NASH-Related Hepatocellular Carcinoma	biomarker_for	disease	0.80
Oxidative Stress	activates	pathway	0.80
GENES	associated_with	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
Cancer	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Cancer	activates	disease	0.75
Als	activates	disease	0.75
Fibrosis	activates	disease	0.75
Aging	activates	disease	0.75
Cancer	contributes_to	disease	0.75
Senescence	activates	disease	0.75
Glioblastoma	activates	disease	0.75
SMARCA4	therapeutic_target	gene	0.70
TP53	activates	gene	0.70
telomere synthesis	activates	process	0.70
cellular senescence	protects_against	process	0.70
NRF2	inhibits	gene	0.70
CDKN2A	associated_with	gene	0.70
EGFR	activates	gene	0.70
Wnt	therapeutic_target	pathway	0.70
Tgf-Β	activates	pathway	0.70
GENES	therapeutic_target	gene	0.70
aging	regulates	process	0.70
Apoptosis	activates	pathway	0.70
Epigenetic	contributes_to	pathway	0.70
Nf-Κb	activates	pathway	0.70
CANCER	activates	gene	0.70
SENESCENCE	protects_against	phenotype	0.70
Arthritis	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	activates	disease	0.65
Senescence	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Hepatitis	activates	disease	0.65

Incoming (205)

Source	Relation	Type	Str
GABPB1	activates	gene	0.90
VEGFA	therapeutic_target	gene	0.70
TAC	activates	drug	0.70
MEK/ERK/AP-1	regulates	pathway	0.70
IDH1	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
SF3B1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
IDH1	associated_with	gene	0.60
TP53	activates	gene	0.60
BRAF	associated_with	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
APOB	associated_with	gene	0.60
EEF1A1	associated_with	gene	0.60
ATRX	associated_with	gene	0.60
GJA1	regulates	gene	0.60
TERC	associated_with	gene	0.60
ACVR2A	activates	gene	0.60
CTNNB1	activates	gene	0.60
BRAF	activates	gene	0.60
EGFR	activates	gene	0.60
RB1	activates	gene	0.60
NF1	activates	gene	0.60
SRC	activates	gene	0.60
STAT3	activates	gene	0.60
ERK1	activates	gene	0.60
CD38	therapeutic_target	gene	0.60
FOXP1	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
LGALS1	expressed_in	gene	0.60
P4HB	expressed_in	gene	0.60
MT2A	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TERT

Understanding Entity Pages

Summary

Wiki Pages (21)

TERT Gene

Longevity and Rejuvenation Therapies Landscape

TERT Gene

eef1a1

Wnt Signaling Dysfunction in Neurodegenerative Diseases

LEF1

GV1001 for Moderate to Severe Alzheimer's Disease (NCT05303701)

ARRB2 — Arrestin Beta 2

Cellular Senescence Disease Comparison

GABPA - GA Binding Protein Transcription Factor Alpha Subunit

TERT Protein

Telomere Dysfunction in Neurodegeneration

RAD50 Gene

KCNN4 — Potassium Calcium-Activated Channel Subfamily N Member 4

Epigenetic Changes in PSP

DNA Methylation

KDM5C (Lysine Demethylase 5C)

Telomere Dysfunction-Associated Neurons

Wnt Signaling Modulation Therapy