Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TBX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive guide to TBX2 gene, a T-box transcription factor involved in development and neurodegenerative diseases including Alzheimer's and Parkinson's
No AI portrait yet
| Gene Symbol | TBX2 |
| Full Name | T-Box Transcription Factor 2 |
| Chromosome | 17q23.2 |
| Protein Type | Transcription Factor |
| Function | is a member of the T-box family of transcription factors that play critical roles in embryonic development, tissue patterning, and cellular differentiation. |
| Primary Expression | the developing and adult brain, where it regulates genes involved in neuronal differentiation, survival, and function |
| Subcellular Localization | **Sumoylation**: Sumoylation of TBX2 may modulate its repressive functions |
| Molecular Weight | 75 kDa |
| Amino Acids | 680 aa |
| Exons | 8 |
| UniProt ID | Q9URJ3 |
| NCBI Gene ID | 6903 |
| GeneCards | TBX2 |
| Human Protein Atlas | TBX2 |
| Activation Domain | Located at amino acids 350-450, this region interacts with transcriptional co-activators and histone acetyltransferases |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TBX2["TBX2"]
neurodegeneration["neurodegeneration"]
TBX2 -->|"implicated_in"| neurodegeneration
style TBX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TBX2 in their description or question text
No additional research found