concept

TCA CYCLE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TCA CYCLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
1Analyses
1Outgoing
13Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameTCA CYCLE
Key Genes/ProteinsAMPK
Related DiseasesCANCER
Linked Hypotheses1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

mechanism · 4869 words

Mitochondrial Dysfunction in Neurodegeneration

mechanism · 4363 words

ATP5F1 — ATP Synthase F1 Subunit Beta

gene · 4040 words

NDUFAF3 Gene

gene · 3956 words

Pathway Diagram

graph TD
    TCA_CYCLE["TCA CYCLE"]
    TCA_CYCLE -->|"product_of"| Fumarate["Fumarate"]
    ACO2["ACO2"] -->|"involved_in"| TCA_CYCLE
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| TCA_CYCLE
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| TCA_CYCLE
    GLYCOLYSIS["GLYCOLYSIS"] -->|"activates"| TCA_CYCLE
    KEAP1["KEAP1"] -->|"activates"| TCA_CYCLE
    NRF2["NRF2"] -->|"activates"| TCA_CYCLE
    MITOPHAGY["MITOPHAGY"] -->|"regulates"| TCA_CYCLE
    PARKIN["PARKIN"] -->|"regulates"| TCA_CYCLE

Outgoing (1)

TargetRelationTypeStr
Fumarateproduct_ofcompound0.95

Incoming (14)

SourceRelationTypeStr
PENTOSE PHOSPHATE PATHWAYactivatesprocess0.35
CANCERactivatesdisease0.35
AMPKactivatesgene0.35
OXIDATIVE PHOSPHORYLATIONimplicated_inprocess0.35
FATTY ACID OXIDATIONimplicated_inprocess0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found