Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TCA CYCLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TCA CYCLE |
| Key Genes/Proteins | AMPK |
| Related Diseases | CANCER |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
TCA_CYCLE["TCA CYCLE"]
TCA_CYCLE -->|"product_of"| Fumarate["Fumarate"]
ACO2["ACO2"] -->|"involved_in"| TCA_CYCLE
OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| TCA_CYCLE
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| TCA_CYCLE
GLYCOLYSIS["GLYCOLYSIS"] -->|"activates"| TCA_CYCLE
KEAP1["KEAP1"] -->|"activates"| TCA_CYCLE
NRF2["NRF2"] -->|"activates"| TCA_CYCLE
MITOPHAGY["MITOPHAGY"] -->|"regulates"| TCA_CYCLE
PARKIN["PARKIN"] -->|"regulates"| TCA_CYCLE| Target | Relation | Type | Str |
|---|---|---|---|
| Fumarate | product_of | compound | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PENTOSE PHOSPHATE PATHWAY | activates | process | 0.35 |
| CANCER | activates | disease | 0.35 |
| AMPK | activates | gene | 0.35 |
| OXIDATIVE PHOSPHORYLATION | implicated_in | process | 0.35 |
| FATTY ACID OXIDATION | implicated_in | process | 0.35 |
| GLYCOLYSIS | implicated_in | process | 0.35 |
| NRF2 SIGNALING | activates | process | 0.35 |
| PENTOSE PHOSPHATE PATHWAY | regulates | process | 0.35 |
| ELECTRON TRANSPORT CHAIN | regulates | process | 0.35 |
| GLYCOLYSIS | regulates | process | 0.35 |
| OXIDATIVE PHOSPHORYLATION | interacts_with | process | 0.35 |
| ELECTRON TRANSPORT CHAIN | interacts_with | process | 0.35 |
| OXIDATIVE STRESS | interacts_with | process | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||