Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Fumarate: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| PRKN | inhibits | protein | 0.95 |
| PRKN | modulates | protein | 0.95 |
| Succination | mediates | process | 0.95 |
| PINK1-Parkin-Mediated Mitophagy | inhibits | pathway | 0.95 |
| Mitophagy | inhibits | process | 0.95 |
| PRKN Cysteine 323 | binds | biomarker | 0.90 |
| PRKN Cysteine 451 | binds | biomarker | 0.90 |
| KEAP1 | binds | protein | 0.85 |
| Parkinson's Disease | contributes_to | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TCA Cycle | product_of | pathway | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||