pathway

GLYCOLYSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLYCOLYSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1413Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	GLYCOLYSIS
Key Genes/Proteins	HIF-1α, PFKFB3
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLYCOLYSIS["GLYCOLYSIS"] -->|"contributes to"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    GLYCOLYSIS["GLYCOLYSIS"] -->|"involved in"| Microglial_Metabolism["Microglial Metabolism"]
    style Microglial_Metabolism fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    GLYCOLYSIS["GLYCOLYSIS"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    GLYCOLYSIS["GLYCOLYSIS"] -->|"promotes"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    GLYCOLYSIS["GLYCOLYSIS"] -->|"regulates"| P53["P53"]
    style P53 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GLYCOLYSIS["GLYCOLYSIS"] -.->|"inhibits"| MTOR["MTOR"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GLYCOLYSIS["GLYCOLYSIS"] -.->|"inhibits"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    HK2["HK2"] -->|"involved in"| GLYCOLYSIS["GLYCOLYSIS"]
    style HK2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PKM2["PKM2"] -->|"involved in"| GLYCOLYSIS["GLYCOLYSIS"]
    style PKM2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MICROGLIA["MICROGLIA"] -->|"involved in"| GLYCOLYSIS["GLYCOLYSIS"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    HIF1A["HIF1A"] -->|"regulates"| GLYCOLYSIS["GLYCOLYSIS"]
    style HIF1A fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PRMT1["PRMT1"] -->|"regulates"| GLYCOLYSIS["GLYCOLYSIS"]
    style PRMT1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style GLYCOLYSIS fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (201)

Target	Relation	Type	Str
NEUROINFLAMMATION	contributes_to	entity	0.90
Microglial Metabolism	involved_in	process	0.85
photoreceptor cells	protects_against	cell_type	0.70
OXIDATIVE PHOSPHORYLATION	phosphorylates	process	0.65
MACROPHAGES	exacerbates	cell_type	0.65
CELL PROLIFERATION	causes	phenotype	0.65
ANGIOGENESIS	activates	phenotype	0.65
NEURONS	produces	cell_type	0.65
VASCULAR DEMENTIA	causes	disease	0.65
METASTASIS	inhibits	phenotype	0.65
LACTATE	causes	phenotype	0.60
LACTATE	produces	phenotype	0.60
ALZHEIMERS_DISEASE	associated_with	disease	0.56
VASCULAR DEMENTIA	expressed_in	disease	0.55
PENTOSE PHOSPHATE PATHWAY	activates	process	0.50
KRAS	inhibits	concept	0.50
PRMT1	inhibits	concept	0.50
Pancreatic Cancer	inhibits	disease	0.50
MTORC1	activates	concept	0.50
Pi3K/Akt	activates	pathway	0.50
Proteins	activates	protein	0.50
GSK3	activates	concept	0.50
LDHA	activates	concept	0.50
LDHB	activates	concept	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
CELL PROLIFERATION	activates	concept	0.50
Macrophage	activates	cell_type	0.50
PERICYTE	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
NADH	associated_with	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
CYTOKINE	activates	concept	0.50
Proteins	expressed_in	protein	0.50
GLUTAMATE	associated_with	concept	0.50
Neuron	activates	cell_type	0.50
Astrocytes	activates	cell_type	0.50
Astrocytes	inhibits	cell_type	0.50
Astrocyte	inhibits	cell_type	0.50
MYELIN	activates	concept	0.50
GLUTAMATE	activates	concept	0.50
NEURONS	regulates	concept	0.50
DIABETIC RETINOPATHY	inhibits	concept	0.50
Retinopathy	inhibits	disease	0.50
DIABETIC RETINOPATHY	activates	concept	0.50
Retinopathy	activates	disease	0.50
Endothelial Cell	inhibits	cell_type	0.50
ENDOTHELIAL	inhibits	concept	0.50
ISCHEMIC	inhibits	concept	0.50
ISCHEMIC STROKE	inhibits	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50

Incoming (1212)

Source	Relation	Type	Str
HK2	involved_in	entity	0.95
PKM2	involved_in	entity	0.95
MICROGLIA	involved_in	entity	0.95
HIF1A	upregulates	entity	0.90
PRMT1	regulates	entity	0.85
AMPK	inhibits	entity	0.85
HIF-1α	upregulates	protein	0.80
PFKFB3	drives	gene	0.80
MICROGLIA	reprograms	cell_type	0.80
Buyang Huanwu Decoction	suppresses	compound	0.80
LACTATE	activates	phenotype	0.65
KRAS	causes	gene	0.65
MTOR SIGNALING	regulates	pathway	0.65
LACTATE	regulates	phenotype	0.65
ASTROCYTE	phosphorylates	cell_type	0.65
TAU	inhibits	protein	0.65
CELL MIGRATION	targets	phenotype	0.65
HDAC3	causes	gene	0.65
LDHA	regulates	gene	0.65
ITGA2B	activates	protein	0.64
ASTROCYTES	stabilizes	cell_type	0.60
GLUTAMATE	causes	phenotype	0.60
LACTATE	stabilizes	phenotype	0.60
HK2	phosphorylates	gene	0.60
HK2	converts	gene	0.60
ASTROCYTES	produces	cell_type	0.60
APOE	activates	gene	0.60
PRDX1	regulates	protein	0.56
LACTATE	expressed_in	phenotype	0.55
CARCINOMA	activates	disease	0.50
GAIN	activates	gene	0.50
HIF-1Α	activates	protein	0.50
cancer	inhibits	disease	0.50
TUMOR	inhibits	disease	0.50
Pi3K	activates	pathway	0.50
GLUT1	activates	protein	0.50
PKM2	activates	protein	0.50
cancer	regulates	disease	0.50
TUMOR	regulates	disease	0.50
PTEN	activates	gene	0.50
mTOR	activates	entity	0.50
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
cancer	associated_with	disease	0.50
MITOCHONDRIA	regulates	cell_type	0.50
PFKL	regulates	protein	0.50
LIPID METABOLISM	regulates	pathway	0.50
TFEB	activates	protein	0.50
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
Neuroinflammation	activates	process	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Metabolic Reprogramming via Microglial Glycolysis Inhibition	0.385	neurodegeneration	Synaptic pruning by microglia in early A

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557]	Sun B, Zhang A, Feng S, Jamali AW, Jia Z	Int Immunopharmacol	2026	1
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352]	Pesce NA, Seminara G, Giarrusso G, Tomas	Adv Biol (Weinh)	2026	1
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285]	Fang M, Zhou Y, He K, Lu Y, Tao F, Huang	Mol Neurobiol	2025	1
Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376]	Sun L, Wang X, Guan S, Zhang P, Chen D,	FASEB J	2025	1
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014]	Fontana F, Giannitti G, Marchesi S, Limo	Int J Biol Sci	2024	1
AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289]	Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh	Mol Med	2024	1
Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576]	Rho H, Terry AR, Chronis C, Hay N	Cell Metab	2023	1
Crosstalk Between [PMID:41899603]	["Ren Y", "Tang D", "Ding X", "He M"]	Cancers	2026	0
Suoquan Yishen formula attenuates ectopic lipid deposition in diabetic kidney di [PMID:41461331]	Wang J, Lin N, Li X, Ma T, Yuan Y et al.	J Ethnopharmacol	2026	0
Yi-Shen-Hua-Shi granules ameliorate renal injury via PPARγ-Klotho-mediated metab [PMID:41475627]	Gao HZ, Sun LM, Hu D, Li J, Chen CL et a	J Ethnopharmacol	2026	0
Bisphenol A Promotes Ovarian Cancer Proliferation and Migration through the HK2/ [PMID:41885081]	Xie X, Zhang Y, Li Y, Yan Q, Dong J et a	J Agric Food Chem	2026	0
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: [PMID:41936633]	Tang Y, Wang S, Wang Y, Zhang T, Liu Y e	Histochem Cell Biol	2026	0
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic [PMID:41945160]	Jian Y, Zeng Y, Wang Z, Zhou X, Zhang H	Apoptosis	2026	0
Nuclear hexokinase 2 couples hyperglycemia to MYC-driven glycolytic and stemness [PMID:41951587]	Liu S, Liu X, Liu G, Wang Z, Li C et al.	Cell Death Dis	2026	0
Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reduc [PMID:41958068]	Gong D, Chen X, Dong Z, Chen H, Liu Z	Ren Fail	2026	0
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates [PMID:41960638]	Lin W, Dong C, Jiang Q, Lou Y, Wang L et	Redox Rep	2026	0
Modulation of Aerobic Glycolysis Genes During the Progression of Retinitis Pigme [PMID:41569027]	["Adani E", "Villa Vasquez S", "Lovino M	Investigative ophthalmology &	2026	0
Duzhong-Gegen formula ameliorated hyperuricemia by enhancing renal uric acid exc [PMID:41905095]	Wang L, Gan Y, Huang J, Long L, Li S, Wa	Phytomedicine : international	2026	0
Mitophagy bridges glucose metabolism, inflammation and neuroprotection in astroc [PMID:41677100]	["Hakansson H", "Howden J", "Kittler J"]	Autophagy	2026	0
Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular De [PMID:41897347]	["Xiao T", "Tao J", "Tan J", "Yi X", "Wa	Biomolecules	2026	0

GLYCOLYSIS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Parthanatos in Neurodegeneration

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Oligodendrocytes

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Coenzyme Q10 for Neurodegeneration

Epigenetic Dysregulation in Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Excitotoxicity in Neurodegeneration

Glia-Neuron Crosstalk in Alzheimer's Disease

ATP5F1 — ATP Synthase F1 Subunit Beta

Astrocytes

Neuroinflammation-Mitochondria Crosstalk Pathway