pathway

OXIDATIVE PHOSPHORYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE PHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1338Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	OXIDATIVE PHOSPHORYLATION
Key Genes/Proteins	SQSTM1, INPP5D
Related Diseases	LIPID DROPLET ACCUMULATION, PYRUVATE, NECROPTOSIS, PYROPTOSIS, CYTOKINES

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| TCA_CYCLE["TCA CYCLE"]
    style TCA_CYCLE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RAS["RAS"]
    style RAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RB1["RB1"]
    style RB1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| RIPK1["RIPK1"]
    style RIPK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"] -->|"activates"| SQSTM1["SQSTM1"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    COMPLEMENT["COMPLEMENT"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style COMPLEMENT fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    IMMUNE_RESPONSE["IMMUNE RESPONSE"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style IMMUNE_RESPONSE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    DENDRITIC_CELL["DENDRITIC CELL"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style DENDRITIC_CELL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    DNA_DAMAGE["DNA DAMAGE"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style DNA_DAMAGE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    EGF["EGF"] -->|"activates"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style EGF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_PHOSPHORYLATION fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (190)

Target	Relation	Type	Str
LIPID DROPLET ACCUMULATION	inhibits	phenotype	0.90
PYRUVATE	activates	phenotype	0.65
NECROPTOSIS	causes	phenotype	0.65
MICROGLIA	treats	cell_type	0.65
PYROPTOSIS	activates	phenotype	0.65
PYROPTOSIS	inhibits	phenotype	0.65
SQSTM1	phosphorylates	gene	0.65
CYTOKINES	interacts_with	phenotype	0.65
ASTROCYTES	produces	cell_type	0.60
RAPAMYCIN	activates	drug	0.50
MTORC1	activates	concept	0.50
Stem Cell	activates	cell_type	0.50
Epithelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
Dendritic Cell	activates	cell_type	0.50
CYP1A1	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
disease	inhibits	disease	0.50
Fatty Liver	inhibits	disease	0.50
Reactive Oxygen Species	inhibits	process	0.50
GLYCOLYSIS	activates	pathway	0.50
GLYCOLYSIS	inhibits	pathway	0.50
Astrocytes	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
GLYCOLYSIS	associated_with	pathway	0.50
Neuroprotection	inhibits	process	0.50
CELL DEATH	causes	concept	0.50
Reactive Oxygen Species	causes	process	0.50
Proteins	causes	protein	0.50
GLYCOLYSIS	regulates	pathway	0.50
NEURONS	regulates	concept	0.50
AXON	causes	concept	0.50
CELL PROLIFERATION	activates	concept	0.50
ORGANOIDS	activates	concept	0.50
MITOCHONDRIAL DNA	associated_with	gene	0.50
CELL CYCLE	regulates	cell_type	0.50
HIPPO	interacts_with	concept	0.50
CELL DEATH	activates	concept	0.50
MTDNA	associated_with	gene	0.50
Mitochondrial Function	associated_with	pathway	0.50
AMYGDALA	expressed_in	concept	0.50
WHITE MATTER	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
CORTEX	associated_with	brain_region	0.50

Incoming (1148)

Source	Relation	Type	Str
MITOCHONDRIA	involved_in	cell_type	0.95
GLYCOLYSIS	phosphorylates	process	0.65
LEUKEMIA	targets	disease	0.65
ISCHEMIA	inhibits	disease	0.65
ASTROCYTES	inhibits	cell_type	0.65
ASTROCYTES	regulates	cell_type	0.65
INPP5D	causes	gene	0.65
OLIGODENDROCYTES	inhibits	cell_type	0.65
AMYLOID	causes	protein	0.65
MFN1	activates	gene	0.60
ROS	destabilizes	phenotype	0.60
INPP5D	implicated_in	gene	0.55
SYNAPTIC PLASTICITY	implicated_in	phenotype	0.55
Pi3K	activates	pathway	0.50
TFEB	activates	protein	0.50
EGFR	activates	gene	0.50
EIF2A	activates	protein	0.50
Autophagy	activates	process	0.50
STING1	activates	protein	0.50
RICTOR	activates	gene	0.50
EIF2AK3	activates	gene	0.50
STAT3	activates	gene	0.50
DEPTOR	activates	gene	0.50
RIPK1	activates	gene	0.50
FIP200	activates	gene	0.50
GABA	activates	gene	0.50
ERN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
PPARG	activates	gene	0.50
GRB2	activates	gene	0.50
RPS6KB1	activates	gene	0.50
HSPA5	activates	gene	0.50
RHEB	activates	gene	0.50
PIK3C3	activates	gene	0.50
RPTOR	activates	gene	0.50
MAP1LC3A	activates	gene	0.50
TFE3	activates	gene	0.50
RB1CC1	activates	gene	0.50
MAPK14	activates	gene	0.50
MAVS	activates	gene	0.50
MLST8	activates	gene	0.50
NBR1	activates	gene	0.50
RIBOSOMAL PROTEIN S6	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
HSP70	activates	protein	0.50
ENDOPHILIN	activates	protein	0.50
P38 Mapk	activates	pathway	0.50
GABARAP	activates	protein	0.50
GRP78	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OXIDATIVE PHOSPHORYLATION

Understanding Entity Pages

Wiki Pages (21)