protein

TET2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TET2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Tet2 Protein is involved in cellular processes relevant to neurodegeneration. For detailed information, refer to the References section.

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🔬 Protein Info

Gene Symbol	TET2PROTEIN
Full Name	Tet Methylcytosine Dioxygenase 2
Chromosome	4q24
Protein Type	Protein
Target Class	Epigenetic Regulator
Function	is a member of the TET family of 5-methylcytosine hydroxylases.
Mechanism of Action	Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation
Subcellular Localization	** Nucleus * Protein Family: TET family (2-oxoglutarate-dependent dioxygenas
Druggability	Low (0.42)
Clinical Stage	Phase II
Molecular Weight	224 kDa
UniProt ID	Search UniProt
GeneCards	TET2PROTEIN
Human Protein Atlas	TET2PROTEIN
TET1 and TET3	Other mammalian TET family members with overlapping
Associated Diseases	AGING, Als, Alzheimer, Alzheimer's Disease
Known Drugs/Compounds	IDH1/2 inhibitors, nicotinamide, Vitamin C
Interactions	AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
SciDEX Target	View Target Profile (6 clinical trials)
SciDEX Hypotheses	Epigenetic Memory Erasure via TET2 Activation TET2-Mediated Demethylation Rejuvenation Therapy Temporal TET2-Mediated Hydroxymethylation Cycling
KG Connections	616 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TET2PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Tet Methylcytosine Dioxygenase 2 Protein

protein · 630 words

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Pathway Diagram

graph TD
    TET2PROTEIN["TET2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TET2PROTEIN -->|"implicated_in"| neurodegeneration
    style TET2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TET2PROTEIN in their description or question text

No additional research found