| Gene Symbol | TET2PROTEIN |
| Full Name | Tet Methylcytosine Dioxygenase 2 |
| Chromosome | 4q24 |
| Protein Type | Protein |
| Target Class | Epigenetic Regulator |
| Function | is a member of the TET family of 5-methylcytosine hydroxylases. |
| Mechanism of Action | Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation |
| Subcellular Localization | ** Nucleus * **Protein Family:** TET family (2-oxoglutarate-dependent dioxygenas |
| Druggability | Low (0.42) |
| Clinical Stage | Phase II |
| Molecular Weight | 224 kDa |
| UniProt ID | Search UniProt |
| GeneCards | TET2PROTEIN |
| Human Protein Atlas | TET2PROTEIN |
| TET1 and TET3 | Other mammalian TET family members with overlapping |
| Associated Diseases | AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE |
| Known Drugs/Compounds | nicotinamide |
| Interactions | TP53, DNMT3A, U2AF1, ASXL1, SF3B1, PSEN1 |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Epigenetic Memory Erasure via TET2 Activation TET2-Mediated Demethylation Rejuvenation Therapy Temporal TET2-Mediated Hydroxymethylation Cycling |
| KG Connections | 634 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |