Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TH, AADC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| TLR4, SNCA | debate_co_mention | gene | 0.45 |
| neurodegeneration | associated_with | disease | 0.40 |
| neurodegeneration | implicated_in | disease | 0.40 |
| TLR4, SNCA | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:TH, AADC | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-7bb47d7a | targets | hypothesis | 0.50 |
| NLRP3 | debate_co_mention | gene | 0.45 |
| NLRP3, CASP1, IL1B, PYCARD | debate_co_mention | gene | 0.45 |
| SNCA | debate_co_mention | gene | 0.45 |
| SNCA, HSPA1A, DNMT1 | debate_co_mention | gene | 0.45 |
| CLDN1, OCLN, ZO1, MLCK | co_associated_with | gene | 0.40 |
| SNCA, HSPA1A, DNMT1 | co_associated_with | gene | 0.40 |
| NLRP3, CASP1, IL1B, PYCARD | co_associated_with | gene | 0.40 |
| GLP1R, BDNF | co_associated_with | gene | 0.40 |
| AHR, IL10, TGFB1 | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:TH, AADC | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Bacterial Enzyme-Mediated Dopamine Precursor Synthesis | 0.364 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Gene therapy for Parkinson's disease: current landscape, translational challenge [PMID:41837837] | Evola V, Parmar MS | Expert review of neurotherapeu | 2026 | 0 |
| Neurosurgical gene therapy for central nervous system diseases. [PMID:39191071] | Patel RV, Nanda P, Richardson RM | Neurotherapeutics : the journa | 2024 | 0 |
| Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC d [PMID:34763085] | Tai CH, Lee NC, Chien YH, Byrne BJ, Mura | Molecular therapy : the journa | 2022 | 0 |
| Gene therapy restores dopamine transporter expression and ameliorates pathology [PMID:34011628] | Ng J, Barral S, De La Fuente Barrigon C, | Science translational medicine | 2021 | 0 |
| Current Clinical Applications of In Vivo Gene Therapy with AAVs. [PMID:33309881] | Mendell JR, Al-Zaidy SA, Rodino-Klapac L | Molecular therapy : the journa | 2021 | 0 |
| Targeting autophagy using small-molecule compounds to improve potential therapy [PMID:34729301] | Zhang K, Zhu S, Li J, Jiang T, Feng L, P | Acta pharmaceutica Sinica. B | 2021 | 0 |
| Graphene bilayers with a twist. [PMID:33208935] | ["Andrei E", "MacDonald A"] | Nature materials | 2020 | 0 |
| Reconstruction of cell spatial organization from single-cell RNA sequencing data [PMID:32541867] | ["Ren X", "Zhong G", "Zhang Q", "Zhang L | Cell research | 2020 | 0 |
| Gene therapy for neurodegenerative disorders: advances, insights and prospects. [PMID:32963936] | Chen W, Hu Y, Ju D | Acta pharmaceutica Sinica. B | 2020 | 0 |
| Ligand entry in human ileal bile acid-binding protein is mediated by histidine p [PMID:30886237] | ["Horv\u00e1th G", "Egyed O", "Tang C", | Scientific reports | 2019 | 0 |
| [Skin Changes in POEMS Syndrome]. [PMID:30988219] | ["Kuwabara S"] | Brain and nerve = Shinkei kenk | 2019 | 0 |
| Consensus guideline for the diagnosis and treatment of aromatic l-amino acid dec [PMID:28100251] | Wassenberg T, Molero-Luis M, Jeltsch K, | Orphanet journal of rare disea | 2017 | 0 |
| Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecho [PMID:27491309] | Nagatsu T, Nagatsu I | Journal of neural transmission | 2016 | 0 |
| Large-scale meta-analysis of genome-wide association data identifies six new ris [PMID:25064009] | ["Nalls M", "Pankratz N", "Lill C", "Do | Nature genetics | 2014 | 0 |
| Reward and aversion in a heterogeneous midbrain dopamine system. [PMID:23578393] | Lammel S, Lim BK, Malenka RC | Neuropharmacology | 2014 | 0 |
| Differential modulation of innate immunity in vitro by probiotic strains of Lact [PMID:24365457] | ["Luongo D", "Miyamoto J", "Bergamo P", | BMC microbiology | 2013 | 0 |
| Antiparkinson prodrugs. [PMID:18259129] | Di Stefano A, Sozio P, Cerasa LS | Molecules (Basel, Switzerland) | 2008 | 0 |
| Assessment of neuroimaging techniques as biomarkers of the progression of Parkin [PMID:14597329] | Brooks DJ, Frey KA, Marek KL, Oakes D, P | Experimental neurology | 2003 | 0 |