Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLRP3, CASP1, IL1B, PYCARD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| SNCA | debate_co_mention | gene | 0.45 |
| SNCA, HSPA1A, DNMT1 | debate_co_mention | gene | 0.45 |
| TH, AADC | debate_co_mention | gene | 0.45 |
| TLR4, SNCA | debate_co_mention | gene | 0.45 |
| neurodegeneration | associated_with | disease | 0.40 |
| neurodegeneration | implicated_in | disease | 0.40 |
| SNCA, HSPA1A, DNMT1 | co_associated_with | gene | 0.40 |
| TH, AADC | co_associated_with | gene | 0.40 |
| TLR4, SNCA | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:NLRP3, CASP1, IL1B, PYCARD | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-e7e1f943 | targets | hypothesis | 0.50 |
| GLP1R | debate_co_mention | gene | 0.45 |
| GLP1R, BDNF | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| NLRP3 | debate_co_mention | gene | 0.45 |
| CLDN1, OCLN, ZO1, MLCK | co_associated_with | gene | 0.40 |
| GLP1R, BDNF | co_associated_with | gene | 0.40 |
| AHR, IL10, TGFB1 | co_associated_with | gene | 0.40 |
| benchmark_ot_ad_answer_key:NLRP3, CASP1, IL1B, PYCARD | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming | 0.607 | neurodegeneration | What are the mechanisms by which gut mic |
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.599 | neurodegeneration | What are the mechanisms by which gut mic |
| Microbial Inflammasome Priming Prevention | 0.584 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Systemic inflammation as a central player in the initiation and development of A [PMID:40841660] | Bayraktaroglu I, Ortí-Casañ N, Van Dam D | Immunity & ageing : I & A | 2025 | 1 |
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradatio [PMID:34486483] | ["Cai B", "Zhao J", "Zhang Y", "Liu Y", | Autophagy | 2022 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877] | Waghmare A, Rahangdale S, Khare K, Taksa | Molecular and cellular neurosc | 2026 | 0 |
| The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436] | Gopalakrishna PK, Che Mohd Nassir CMN, A | Cellular and molecular neurobi | 2026 | 0 |
| Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter [PMID:41687275] | Otálora-Alcaraz A, Sun MC, Hofman N, Cos | Multiple sclerosis and related | 2026 | 0 |
| NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adip [PMID:41596350] | Alenezi SA, Alshammari K, Khan R, Amer S | International journal of molec | 2026 | 0 |
| Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222] | Ortiz-Samur NS, Vijaya AK, Burokas A, Me | Journal of neurochemistry | 2025 | 0 |
| Sepsis and the Liver. [PMID:41439929] | ["Geladari E", "Kalergi A", "Evangelopou | Diseases (Basel, Switzerland) | 2025 | 0 |
| Molecular links between inflammatory bowel disease and Alzheimer's disease throu [PMID:41480321] | Durairajan SSK, Singh AK, Sulaiman SM, P | World journal of gastroenterol | 2025 | 0 |
| Bone marrow vacuolization to curative strategies: Evolving paradigms in VEXAS sy [PMID:40784090] | ["Elbadry M", "Mabed M"] | Current research in translatio | 2025 | 0 |
| Δ9-Tetrahydrocannabinol and cannabidiol selectively suppress toll-like receptor [PMID:40553974] | Sermet S, Finn BM, Crawford RB, Kaminski | The Journal of pharmacology an | 2025 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | International journal of molec | 2025 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | Int J Mol Sci | 2025 | 0 |
| The NLRP3-inflammasome inhibitor MCC950 improves cardiac function in a HFpEF mou [PMID:39616735] | ["Li S", "Withaar C", "Rodrigues P", "Zi | Biomedicine & pharmacotherapy | 2024 | 0 |
| Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation [PMID:38808326] | Yu Y, Miao TW, Xiao W, Mao B, Du LY, Wan | Drug design, development and t | 2024 | 0 |
| GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis thro [PMID:36289519] | ["Liu M", "Li H", "Yang R", "Ji D", "Xia | Journal of neuroinflammation | 2022 | 0 |
| T cell-oriented strategies for controlling the COVID-19 pandemic. [PMID:34497383] | ["Noh J", "Jeong H", "Kim J", "Shin E"] | Nature reviews. Immunology | 2021 | 0 |
| Norethisterone and its acetate - what's so special about them? [PMID:32398290] | Huvinen E, Holopainen E, Heikinheimo O | BMJ sexual & reproductive heal | 2021 | 0 |