Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLRP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NLRP3 is a protein involved in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 1473 entities in the SciDEX knowledge graph.
| Gene Symbol | NLRP3 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | In the healthy nervous system, NLRP3: - Provides innate immune surveillance - Responds to pathogen-associated molecular patterns (PAMPs) - Initiates inflammatory responses to cellular stress - Facilit |
| Mechanism of Action | Small molecule inhibitors targeting NLRP3 inflammasome assembly or activation |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Molecular Weight | 118 kDa |
| Pathways | Adaptive Immunity, Ampk Signaling, Amyloid, Apoptosis, Autophagy |
| UniProt ID | A0A7I2R3P8 |
| GeneCards | NLRP3 |
| Human Protein Atlas | NLRP3 |
| IL-1β | Potent pro-inflammatory cytokine that sustains microglial activation, disrupts dopamine metabolism, and promotes additional α-synuclein aggregation |
| IL-18 | Enhances IFN-γ production, driving Th1 polarization and chronic neuroinflammation |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER, Aging |
| Known Drugs/Compounds | RAPAMYCIN, METFORMIN, FINGOLIMOD, MCC950, nigericin, ruxolitinib |
| Interactions | CASP1, IL1B, PYCARD, ABCD3, FIP200, RTN3 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | NLRP3/Mitophagy Coupling Modulation |
| KG Connections | 4809 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
NLRP3["NLRP3"] -->|"associated with"| Inflammation["Inflammation"]
TNF["TNF"] -->|"associated with"| NLRP3["NLRP3"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| NLRP3["NLRP3"]
AMYLOID["AMYLOID"] -->|"associated with"| NLRP3["NLRP3"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| NLRP3["NLRP3"]
end
subgraph Signaling["Signaling"]
NLRP3["NLRP3"] -->|"activates"| Inflammasome["Inflammasome"]
NLRP3["NLRP3"] -.->|"inhibits"| Inflammation_1["Inflammation"]
NLRP3["NLRP3"] -.->|"inhibits"| Als["Als"]
NLRP3["NLRP3"] -.->|"inhibits"| Inflammasome_2["Inflammasome"]
NLRP3["NLRP3"] -->|"activates"| Inflammation_3["Inflammation"]
NLRP3["NLRP3"] -->|"activates"| Autophagy["Autophagy"]
NLRP3["NLRP3"] -->|"activates"| Als_4["Als"]
NLRP3["NLRP3"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
MICROGLIA["MICROGLIA"] -->|"activates"| NLRP3["NLRP3"]
ROS["ROS"] -->|"activates"| NLRP3["NLRP3"]
end
style NLRP3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammasome_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AMYLOID fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ROS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ASC | activates | protein | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Inflammasome | inhibits | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Pyroptosis | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Neuroinflammation | inhibits | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| PYROPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| Inflammasome | regulates | pathway | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| IL-6 | inhibits | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| TNF-Α | inhibits | gene | 1.00 |
| CYTOKINES | inhibits | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| NLRP3 Inflammasome | involved_in | process | 0.95 |
| IL18 | activates | protein | 0.95 |
| Inflammasome Activation | involved_in | process | 0.95 |
| Inflammatory Cytokine Secretion | activates | process | 0.95 |
| UPREGULATES | upregulates | entity | 0.95 |
| NLRP3 Inflammasome | component_of | pathway | 0.95 |
| Inflammasome Activation | mediates | process | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TNF | associated_with | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| AMYLOID | associated_with | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | disease | 1.00 |
| IL-1B | associated_with | gene | 1.00 |
| IL-6 | associated_with | gene | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| NEUROINFLAMMATION | activates | gene | 0.98 |
| Kaempferol | inhibits | compound | 0.95 |
| P62 | degrades | protein | 0.95 |
| Ams-17 | inhibits | compound | 0.95 |
| sevoflurane | activates | drug | 0.95 |
| Berberine | inhibits | compound | 0.95 |
| Irisin | inhibits | protein | 0.95 |
| TLR2 | activates | gene | 0.95 |
| Aβ1-42 | activates | biomarker | 0.95 |
| Qingqi Liangying Formula | inhibits | drug | 0.95 |
| XHP | activates | drug | 0.95 |
| Damps | activates | compound | 0.95 |
| PCBMA-TAPP | activates | compound | 0.95 |
| Pterostilbene | binds | compound | 0.95 |
| Pterostilbene | inhibits | compound | 0.95 |
| Litebamine | inhibits | compound | 0.95 |
| USP22 | inhibits | protein | 0.95 |
| Microglia | expressed_in | cell_type | 0.95 |
| AUTOPHAGY | suppresses | process | 0.95 |
| NLRP3 inflammasome inhibitors | inhibits | drug | 0.93 |
| Tnea Therapy | inhibits | drug | 0.93 |
| Alpha-Synuclein | activates | protein | 0.93 |
| TFEB | promotes | protein | 0.92 |
| ARRB2 | interacts_with | protein | 0.92 |
| Cyclosporine A | upregulates | drug | 0.92 |
| Cerebral Ischemia-Reperfusion Injury | upregulates | disease | 0.92 |
| AUTOPHAGY | downregulates | entity | 0.92 |
| NF-κB | upstream_of | pathway | 0.92 |
| ARRB2 | modulates | protein | 0.91 |
| Hypoxic-Ischemic Brain Injury | upregulates | disease | 0.91 |
| MCC950 | inhibits | drug | 0.90 |
| STAT3 | regulates | protein | 0.90 |
| SLC25A3 | inhibits | protein | 0.90 |
| SLC25A3 | interacts_with | protein | 0.90 |
| Urolithin A | inhibits | drug | 0.90 |
| TREM2 | inhibits | entity | 0.90 |
| Autophagy-Lysosome Pathway | degrades | pathway | 0.90 |
| P62-Dependent Autophagy | mediates | pathway | 0.90 |
| NRF2 | downregulates | entity | 0.90 |
| SQSTM1 | mediates | entity | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming | 0.607 | neurodegeneration | What are the mechanisms by which gut mic |
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.599 | neurodegeneration | What are the mechanisms by which gut mic |
| NLRP3/Mitophagy Coupling Modulation | 0.522 | Neuroinflammation | Immune atlas neuroinflammation analysis |
Scientific analyses that reference this entity
neuroscience | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.519
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alz [PMID:39862777] | Wang H, Xia H, Bai J, Wang Z, Wang Y et | J Hazard Mater | 2025 | 0 |
| The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic [PMID:40826276] | Weber ANR, McManus RM, Hornung V, Geyer | Nat Immunol | 2025 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | Int J Mol Sci | 2025 | 0 |
| HSP90β controls NLRP3 autoactivation. [PMID:38416826] | Spel L, Hou C, Theodoropoulou K, Zaffalo | Sci Adv | 2024 | 0 |
| NLRP3 inflammasome signalling in Alzheimer's disease. [PMID:38565393] | McManus RM, Latz E | Neuropharmacology | 2024 | 0 |
| P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Pro [PMID:38993566] | Chen L, Liu Y, Yue S, Wang H, Chen J et | Int J Biol Sci | 2024 | 0 |
| The NLRP3 inflammasome: contributions to inflammation-related diseases. [PMID:37370025] | Chen Y, Ye X, Escames G, Lei W, Zhang X | Cell Mol Biol Lett | 2023 | 0 |
| Microglia and Alzheimer's Disease. [PMID:36361780] | Merighi S, Nigro M, Travagli A, Gessi S | Int J Mol Sci | 2022 | 0 |
| Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Co [PMID:34612661] | Qu S, Fan L, Qi Y, Xu C, Hu Y et al. | Microbiol Spectr | 2021 | 0 |
| Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impair [PMID:33584302] | Huang S, Liu H, Lin Y, Liu M, Li Y et al | Front Pharmacol | 2020 | 0 |
| Human Monocytes Engage an Alternative Inflammasome Pathway. [PMID:27037191] | Gaidt MM, Ebert TS, Chauhan D, Schmidt T | Immunity | 2016 | 0 |
| Inflammasome and toll-like receptor signaling in human monocytes after successfu [PMID:27260481] | Asmussen A, Fink K, Busch HJ, Helbing T, | Crit Care | 2016 | 0 |
| Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is respon [PMID:24879148] | Guo W, Sun Y, Liu W, Wu X, Guo L et al. | Autophagy | 2014 | 0 |
| NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS [PMID:23254930] | Heneka MT, Kummer MP, Stutz A, Delekate | Nature | 2013 | 0 |