Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIA1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TIA1L is a TIA1-like RNA binding protein involved in stress granule formation and RNA metabolism, implicated in neurodegenerative diseases including ALS and FTD
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| Gene Symbol | TIA1L |
| Full Name | TIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like) |
| Aliases | TIA-1 Like Protein |
| Chromosome | 19p13.3 |
| Protein Type | Gene |
| Function | is a member of the TIA family of RNA binding proteins that plays critical roles in post-transcriptional gene regulation, stress granule assembly, and RNA metabolism. |
| Primary Expression | the brain, particularly in neurons of the cortex, hippocampus, and basal ganglia, where it participates in translational control and stress response p |
| Molecular Weight | 45 kDa |
| Amino Acids | 420 aa |
| Ensembl ID | ENSG00000134827 |
| GeneCards | TIA1L |
| Human Protein Atlas | TIA1L |
| Cortex | High expression in pyramidal neurons of layers II-VI |
| Hippocampus | Particularly abundant in CA1-CA3 pyramidal neurons and dentate gyrus granule cells |
| Basal ganglia | Significant expression in striatal medium spiny neurons |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TIA1L["TIA1L"]
neurodegeneration["neurodegeneration"]
TIA1L -->|"implicated_in"| neurodegeneration
style TIA1L fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TIA1L in their description or question text
No additional research found