gene 2,599 words KG: TIA1L 2026-03-27
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:alstopic:ftd
Contents

TIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like)

🧬 Gene Info
Gene SymbolTIA1L
Full NameTIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like)
AliasesTIA-1 Like Protein
Chromosome19p13.3
Protein TypeGene
Functionis a member of the TIA family of RNA binding proteins that plays critical roles in post-transcriptional gene regulation, stress granule assembly, and RNA metabolism.
Primary Expressionthe brain, particularly in neurons of the cortex, hippocampus, and basal ganglia, where it participates in translational control and stress response p
Molecular Weight45 kDa
Amino Acids420 aa
NCBI Gene IDSearch NCBI
Ensembl IDENSG00000134827
GeneCardsTIA1L
Human Protein AtlasTIA1L
Associated DiseasesAlzheimer's disease, Parkinson's disease, ALS
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (15)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.42
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in