gene

TMEM65

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM65: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

Summary

Transmembrane Protein 65 gene encoding a mitochondrial inner membrane protein involved in oxidative phosphorylation, Complex I assembly, and implicated in Alzheimer's and Parkinson's disease through mitochondrial dysfunction mechanisms

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🧬 Gene Info

Gene Symbol	TMEM65
Full Name	Transmembrane Protein 65
Chromosome	8q24.3
Function	encodes a mitochondrial inner membrane protein that plays critical roles in oxidative phosphorylation, mitochondrial complex I assembly, and metabolic regulation.
Primary Expression	Heart, brain (neurons), skeletal muscle, liver, kidney
Subcellular Localization	Mitochondrial inner membrane
Molecular Weight	~43.5 kDa
Amino Acids	384 aa
Exons	4
UniProt ID	Q9P0M4
NCBI Gene ID	65078
Ensembl ID	ENSG00000143357
OMIM	616613
GeneCards	TMEM65
Human Protein Atlas	TMEM65
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TMEM65 — AlphaFold Q9P0M4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TMEM65["TMEM65"]
    neurodegeneration["neurodegeneration"]
    TMEM65 -->|"implicated_in"| neurodegeneration
    style TMEM65 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found