gene 1,779 words KG: TMEM65 2026-03-29
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

TMEM65 Gene

🧬 Gene Info
Gene SymbolTMEM65
Full NameTransmembrane Protein 65
Chromosome8q24.3
Functionencodes a mitochondrial inner membrane protein that plays critical roles in oxidative phosphorylation, mitochondrial complex I assembly, and metabolic regulation.
Primary ExpressionHeart, brain (neurons), skeletal muscle, liver, kidney
Subcellular LocalizationMitochondrial inner membrane
Molecular Weight~43.5 kDa
Amino Acids384 aa
Exons4
UniProt IDQ9P0M4
NCBI Gene ID65078
Ensembl IDENSG00000143357
OMIM616613
GeneCardsTMEM65
Human Protein AtlasTMEM65
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in