Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNFα: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | mediates | process | 0.82 |
| NF-κB1 | activates | gene | 0.80 |
| cholesterol metabolism | disrupts | process | 0.80 |
| Neuroinflammation | mediates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Methamphetamine | upregulates | drug | 0.90 |
| Protective Apoe Variants | downregulates | variant | 0.90 |
| Bv2 Microglia Cells | expressed_in | cell_type | 0.85 |
| Hesperetin | inhibits | drug | 0.85 |
| DS-HMGB1 | upregulates | protein | 0.85 |
| EPILEPSY | associated_with | gene | 0.80 |
| Hippo | regulates | pathway | 0.70 |
| P2RX7 | interacts_with | gene | 0.60 |
| EPILEPSY | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Combinatorial Il-1α/TNFα/C1q Antagonism with Selective Agoni | 0.000 | - | Astrocyte Reactivity Subtypes in Neurode |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TNFα in their description or question text
No additional research found