concept

HIPPO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIPPO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

639Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

18Experiments

0Debates

Summary

HIPPO is a concept in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 425 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIPPO
Key Genes/Proteins	ABCB1, ACSL4, Actin, AGING, AKT, ALS
Related Diseases	Addiction, Aging, Als, Alzheimer
Related Pathways	Akt, Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hippo Signaling Pathway in Neurodegeneration

mechanism · 1922 words

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Pathway Diagram

graph TD
    HIPPO["HIPPO"]
    HIPPO -->|"interacts"| FoxO1["FoxO1"]
    HIPPO -->|"regulates"| TNF_["TNFalpha"]
    HIPPO -->|"regulates"| IL_6["IL-6"]
    HIPPO -->|"regulates"| Carcinoma["Carcinoma"]
    HIPPO -->|"regulates"| Als["Als"]
    HIPPO -->|"target for"| Ms["Ms"]
    HIPPO -->|"target for"| Inflammation["Inflammation"]
    HIPPO -->|"activates"| Cancer["Cancer"]
    HIPPO -->|"target for"| Tumor["Tumor"]
    CDH1["CDH1"] -->|"regulates"| HIPPO
    MPXV["MPXV"] -->|"regulates"| HIPPO
    MTOR["MTOR"] -->|"regulates"| HIPPO
    AGING["AGING"] -->|"inhibits"| HIPPO
    GAL["GAL"] -->|"regulates"| HIPPO
    FOS["FOS"] -->|"contributes to"| HIPPO
    MT_ATP6["MT-ATP6"] -->|"regulates"| HIPPO
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| HIPPO
    PI3K["PI3K"] -->|"regulates"| HIPPO

Outgoing (414)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Cancer	regulates	disease	1.00
Hippo Pathway	regulates	pathway	1.00
YAP	activates	gene	1.00
Apoptosis	regulates	pathway	0.90
Cancer	activates	disease	0.85
Als	regulates	disease	0.85
Tumor	regulates	disease	0.85
Gastric Cancer	associated_with	disease	0.80
Apoptosis	activates	pathway	0.80
CANCER	therapeutic_target	gene	0.80
CANCER	activates	gene	0.80
Differentiation	therapeutic_target	pathway	0.80
YAP	associated_with	gene	0.80
MYC	activates	gene	0.80
YAP	regulates	gene	0.80
AKT	activates	gene	0.80
Inflammation	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Carcinoma	regulates	disease	0.75
Als	associated_with	disease	0.75
Tumor	activates	disease	0.75
IL-6	regulates	protein	0.70
Wnt	associated_with	pathway	0.70
INFLAMMATION	therapeutic_target	gene	0.70
Tgf-Β	associated_with	pathway	0.70
Autophagy	regulates	pathway	0.70
AKT	therapeutic_target	gene	0.70
Autophagy	activates	pathway	0.70
Angiogenesis	therapeutic_target	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
Hippo Pathway	associated_with	pathway	0.70
Hedgehog	regulates	pathway	0.70
TNFα	regulates	protein	0.70
Ferroptosis	regulates	pathway	0.70
FERROPTOSIS	regulates	gene	0.70
Hippo Pathway	therapeutic_target	pathway	0.70
CANCER	regulates	gene	0.70
Epigenetic	therapeutic_target	pathway	0.70
FoxO1	interacts_with	protein	0.70
Mtor	regulates	pathway	0.70
EGF	activates	gene	0.70
Metastasis	therapeutic_target	pathway	0.70
STAT3	associated_with	gene	0.70
YAP1	activates	gene	0.70
GENES	regulates	gene	0.70
Tumor	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65

Incoming (225)

Source	Relation	Type	Str
CANCER	regulates	gene	0.80
APOPTOSIS	regulates	gene	0.80
CANCER	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
MST1	regulates	gene	0.70
APOPTOSIS	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
TAZ	regulates	gene	0.70
EGFR	activates	gene	0.70
CDH1	regulates	gene	0.70
PI3K	associated_with	gene	0.70
CLCN8	associated_with	gene	0.70
MPXV	regulates	disease	0.64
ERK	inhibits	gene	0.60
SRC	inhibits	gene	0.60
MIRNAS	activates	gene	0.60
KCNMA1	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
PIEZO1	associated_with	gene	0.60
CANCER	activates	gene	0.60
MYC	activates	gene	0.60
MARK4	activates	gene	0.60
ATG	activates	gene	0.60
TAZ	activates	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
INSULIN RESISTANCE	therapeutic_target	gene	0.60
VEGF	therapeutic_target	gene	0.60
ALS	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
YAP	associated_with	gene	0.60
AKT	associated_with	gene	0.60
DDB1	regulates	gene	0.60
RNA	regulates	gene	0.60
ROS	activates	gene	0.60
ACSL4	activates	gene	0.60
SLC7A11	activates	gene	0.60
GPX4	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
GSH	activates	gene	0.60
WNT	associated_with	gene	0.60
AQP4	activates	gene	0.60
GATA3	activates	gene	0.60
GATA2	activates	gene	0.60
HDAC2	regulates	protein	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.955	alzheimers	Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy	0.946	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	alzheimers	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.885	alzheimers	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound to restore hippo	0.865	alzheimers	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	alzheimers	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	alzheimers	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.820	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.767	alzheimers	Circuit-level neural dynamics in neurode
Cholinergic Basal Forebrain-Hippocampal Circuit Protection	0.760	neuroscience	Circuit-level neural dynamics in neurode
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.751	neuroscience	Circuit-level neural dynamics in neurode
Gamma entrainment suppresses hippocampal ERK1/2 hyperactivit	0.711	alzheimers	Gamma entrainment therapy to restore hip
Gamma entrainment corrects AD-related clock gene dysregulati	0.676	alzheimers	Gamma entrainment therapy to restore hip
Adaptive Closed-Loop Gamma/Theta-Gamma Entrainment of Entorh	0.670	alzheimers	Closed-loop transcranial focused ultraso
Locus Coeruleus-Hippocampal Circuit Protection	0.668	neuroscience	Circuit-level neural dynamics in neurode
VEGF-family genetic control of vascular-neuronal coupling in	0.626	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.622	alzheimers	Circuit-level neural dynamics in neurode
Cell-state stratification is required to resolve VEGF Family	0.612	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
BDNF-mediated hippocampal synaptic rescue as a modifier of C	0.604	neurodegeneration	AD Master Plan preregistration: BDNF
Closed-loop transcranial alternating current stimulation to	0.603	alzheimers	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.584	alzheimers	Circuit-level neural dynamics in neurode
TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam	0.577	neurodegeneration	RNA binding protein dysregulation across
Closed-Loop Hippocampal TFUS for Gamma Network Target Engage	0.575	alzheimers	Closed-loop transcranial focused ultraso
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.573	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.000	alzheimers	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with gamma entra	0.000	alzheimers	Circuit-level neural dynamics in neurode

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (18)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	0.00	mouse models of Alzheimer's di	proposed	N/A
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	0.00	Spp1 knockout AD mouse models	proposed	N/A
Synaptic plasticity and protein expression analysis in mPFC	exploratory	insomnia-anxiety comorbidity	0.850	0.00	mPFC brain slices from PCPA-tr	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int	in_vivo	Alzheimer's disease	0.765	0.55	APP/PS1 mice 8-11 months (n=10	abandoned	$125,000
tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal	in_vivo	Alzheimer's disease	0.744	0.48	hAPP-J20 mice (n=10/group x 3	abandoned	$110,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	completed	$6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Animal Model Comparison for Neurodegenerative Disease Therapeutics	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787]	Tomioka R, Kobayashi K, Song WJ	Neuroscience	2026	0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202]	Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh	Theranostics	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466]	Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H	Korean J Ophthalmol	2026	0
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026	0
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026	0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871]	Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo	Science translational medicine	2026	0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733]	Liu K, Zhang XY, Wang YT, Wang R, Jin RH	Molecular neurobiology	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HIPPO in their description or question text

HIPPO

Understanding Entity Pages

Summary

Wiki Pages (1)

Hippo Signaling Pathway in Neurodegeneration

Pathway Diagram

Outgoing (414)

Incoming (225)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (18)

Related Papers (20)

Debates (0)

Related Research

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Cholinergic Basal Forebrain-Hippocampal Circuit Protection

Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection

Gamma entrainment suppresses hippocampal ERK1/2 hyperactivity to decrease AD-rel

Gamma entrainment corrects AD-related clock gene dysregulation to normalize hipp

Adaptive Closed-Loop Gamma/Theta-Gamma Entrainment of Entorhinal-Hippocampal Cir

Locus Coeruleus-Hippocampal Circuit Protection

VEGF-family genetic control of vascular-neuronal coupling in vulnerable hippocam

Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier opening