Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNFRSF25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| Aging Exosome Pathway | mediates | pathway | 0.80 |
| cognitive_decline | promotes | phenotype | 0.50 |
| neurodegeneration | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| aged_exosomes | activates | cellular_component | 0.50 |
| h-678435d0 | targets | hypothesis | 0.45 |
| AP1S1 | co_associated_with | gene | 0.40 |
| Cell-type specific vulnerability markers | co_associated_with | gene | 0.40 |
| Mitochondrial respiratory complexes and inflammatory cytokine receptors | co_associated_with | gene | 0.40 |
| CGAS, STING1 | co_associated_with | gene | 0.40 |
| CXCL10 | co_associated_with | gene | 0.40 |
| PFN1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TNFRSF25-Mediated Aging Exosome Pathway Inhibition | 0.412 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer. [PMID:41605339] | Fang W, Du J, Xu Z, Liu Q, Liu Y et al. | Crit Rev Oncol Hematol | 2026 | 0 |
| Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES an [PMID:41693749] | Deng C, He Z, Zhu X | SAGE Open Med | 2026 | 0 |
| The involvement of TNFRSF25 in age-related hearing loss. [PMID:41882185] | Roche MV, Tang PC, Yan D, De Marchena MR | Hum Genet | 2026 | 0 |
| Maternal immune activation perturbs intestinal niche through microbial glyceroph [PMID:41926285] | Chang H, Zhu X, Shen C, Xu X, Ni Y et al | Cell Rep | 2026 | 0 |