PFN1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PFN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Actin-binding protein regulating cytoskeletal dynamics, mutations linked to familial ALS pathogenesis

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flowchart TD
    N0["PFN1"]
    N1["Als"]
    N0 -->|"associated with"| N1
    N2["Neurodegeneration"]
    N0 -->|"contributes to"| N2
    N0 -->|"stabilizes"| N2
    N3["ALS"]
    N0 -->|"associated with"| N3
    N4["GAIN"]
    N0 -->|"associated with"| N4
    N5["AND"]
    N0 -->|"expressed in"| N5
    N6["Protein Aggregation"]
    N0 -->|"contributes to"| N6
    N7["DNAJB6"]
    N7 -->|"activates"| N0
    N4 -->|"associated with"| N0
    N8["NEURODEGENERATION"]
    N8 -->|"contributes to"| N0
    N3 -->|"associated with"| N0
    N9["Spinal Cord"]
    N0 -->|"expressed in"| N9
    N10["disease"]
    N0 -->|"associated with"| N10
    N0 -->|"associated with"| N6

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 pathway
    class N7 gene
    class N8 gene
    class N10 disease