Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AP1S1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| vesicular_transport | regulates | pathway | 0.50 |
| neurodegeneration | associated_with | disease | 0.50 |
| TNFRSF25 | co_associated_with | gene | 0.40 |
| Mitochondrial respiratory complexes and inflammatory cytokine receptors | co_associated_with | gene | 0.40 |
| CGAS, STING1 | co_associated_with | gene | 0.40 |
| CXCL10 | co_associated_with | gene | 0.40 |
| PFN1 | co_associated_with | gene | 0.40 |
| Cell-type specific vulnerability markers | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-4639c944 | targets | hypothesis | 0.60 |
| aging | downregulates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| AP1S1-Mediated Vesicular Transport Restoration | 0.416 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||