Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2 upregulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| microglial transition states | activates | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cell-Type Specific TREM2 Upregulation in DAM Microglia | 0.761 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618
neurodegeneration | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.774
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.886
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice | validation | Alzheimer's disease | 0.950 | 0.00 | APP/PS1 transgenic mice (8 mon | proposed | N/A |
| Curcumin-Licorice Combination in D-galactose/Sodium Nitrite AD Model | validation | Alzheimer's disease | 0.950 | 0.00 | C57BL/6 mice | proposed | N/A |
| SPP1 upregulation in perivascular cells in AD mouse models | exploratory | Alzheimer's disease | 0.900 | 0.00 | AD mouse models | proposed | N/A |
| Tet2 modulation in Aβ42-injured mouse hippocampal neurons | exploratory | Alzheimer's disease | 0.900 | 0.00 | primary mouse hippocampal neur | proposed | N/A |
| AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study | validation | Alzheimer's disease | 0.900 | 0.00 | young APPswe/PSEN1 double-tran | proposed | N/A |
| Cerebrovascular function analysis in CD2AP mutant mice | validation | Alzheimer's disease | 0.900 | 0.00 | mice | proposed | N/A |
| Cerebral blood flow regulation in CD2AP mutant mice | validation | Alzheimer's disease | 0.880 | 0.00 | mice | proposed | N/A |
| Abeta-induced cell death and aggregation in GD3S-deficient neurons | exploratory | Alzheimer's disease | 0.850 | 0.00 | primary neurons and astrocytes | proposed | N/A |
| Generation of Aβ-specific Tregs using CRISPR-Cas9 | exploratory | Alzheimer's disease | 0.850 | 0.00 | engineered Tregs | proposed | N/A |
| Cell-cell interaction analysis of perivascular-microglial crosstalk | exploratory | Alzheimer's disease | 0.800 | 0.00 | AD mouse models | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Integrated multimodal cell atlas of Alzheimer’s disease [PMID:37292694] | Gabitto MI, Travaglini KJ, Rachleff VM, | Research Square | 2023 | 63 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852] | ["Ramirez G", "Hernandez D", "Teal A", " | Research square | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven Gamze; Gezegen Haşim; & | Acta neurologica Belgica | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759] | Ishizu H, Hasegawa T, Shimizu T, Yamamot | Bone | 2026 | 0 |
| Oxaliplatin-artesunate conjugate intensifies suppression on colorectal cancer by [PMID:41520444] | Tan Y, Yang T, Jiang S, Li S, Cai L et a | J Inorg Biochem | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
| Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell [PMID:41928407] | Shen HC, Chen NJ, Sun CY, Yu WK, Su VY e | Kaohsiung J Med Sci | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Population-scale burden analysis of rare damaging coding variants identifies nov [PMID:41867223] | Le Guen Y, Peña-Tauber A, Pulgrossi RC, | medRxiv : the preprint server | 2026 | 0 |
| TREM2 as a possible link between Alzheimer's disease and diabetes mellitus. [PMID:41862118] | Chen W, Huang N, Huang W, Wang M, Luo Y, | Experimental neurology | 2026 | 0 |
| The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542] | Ahmed S, Bowers C, Munoz-Martin J, Jamwa | Brain, behavior, and immunity | 2026 | 0 |
| Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms. [PMID:40938771] | Kakkar A, Singh H, Singh BK, Kumar A, Mi | Journal of Alzheimer's disease | 2025 | 0 |
| Dehydroervatamine as a promising novel TREM2 agonist, attenuates neuroinflammati [PMID:39609160] | Li L, Xu N, He Y, Tang M, Yang B, Du J, | Neurotherapeutics : the journa | 2025 | 0 |
| TREM2 regulates microglial lipid droplet formation and represses post-ischemic b [PMID:38042110] | Wei W, Zhang L, Xin W, Pan Y, Tatenhorst | Biomedicine & pharmacotherapy | 2024 | 0 |
| Defects in lysosomal function and lipid metabolism in human microglia harboring [PMID:37115208] | Filipello F, You SF, Mirfakhar FS, Mahal | Acta neuropathologica | 2023 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.93 · 2026-04-06
closed · Rounds: 4 · Score: 0.89 · 2026-04-02
closed · Rounds: 4 · Score: 0.57 · 2026-04-01
Hypotheses and analyses mentioning TREM2 upregulation in their description or question text
No additional research found