Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUBA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TUBA1A encodes the major neuronal alpha-tubulin isoform, critical for microtubule assembly, axonal transport, and neuronal polarity. Mutations cause lissencephaly and microtubule defects in AD/PD.
| Gene Symbol | TUBA1A |
| Full Name | TUBA1A — Tubulin Alpha 1A |
| Chromosome | 12q13.12 |
| Protein Type | Gene |
| Function | is a gene located on chromosome 12q13. |
| Primary Expression | neurons of the developing and adult central nervous system |
| Molecular Weight | 50 kDa |
| Amino Acids | 450 aa |
| Exons | 5 |
| NCBI Gene ID | Search NCBI |
| GeneCards | TUBA1A |
| Human Protein Atlas | TUBA1A |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["TUBA1A"]
N1["Bpmc"]
N1 -->|"downregulates"| N0
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Bpmc | downregulates | compound | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||