concept

BPMC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BPMC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

36Outgoing

18Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	BPMC
Key Genes/Proteins	ACHE, GFAP, MYELIN, MBP, GAP43, NEURON
Related Diseases	DEVELOPMENTAL_NEUROTOXICITY, ALS, Inflammation, Als
Related Pathways	OXIDATIVE_STRESS, INFLAMMATION, APOPTOSIS, Oxidative Stress

Wiki Pages (2)

Knowledge base pages for this entity

CASP3 Protein — Caspase-3

protein · 639 words

→

GAP43 Gene

gene · 522 words

→

Pathway Diagram

graph TD
    BPMC["BPMC"]
    BPMC -->|"causes"| Developmental_Neurotoxicity["Developmental Neurotoxicity"]
    BPMC -->|"upregulates"| Reactive_Oxygen_Species_Produc["Reactive Oxygen Species Production"]
    BPMC -->|"activates"| CASP3["CASP3"]
    BPMC -->|"activates"| CASP9["CASP9"]
    BPMC -->|"downregulates"| ACHE["ACHE"]
    BPMC -->|"causes"| Reduced_Motility["Reduced Motility"]
    BPMC -->|"upregulates"| ROS_Production["ROS Production"]
    TUBULIN["TUBULIN"] -->|"inhibits"| BPMC
    SYN2A["SYN2A"] -->|"inhibits"| BPMC
    ACHE -->|"inhibits"| BPMC
    GAP43["GAP43"] -->|"inhibits"| BPMC
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| BPMC
    MANF["MANF"] -->|"inhibits"| BPMC
    ROS["ROS"] -->|"activates"| BPMC
    AXON["AXON"] -->|"activates"| BPMC

Outgoing (55)

Target	Relation	Type	Str
Mbp	downregulates	entity	0.85
DEVELOPMENTAL_NEUROTOXICITY	causes	phenotype	0.72
ACHE	inhibits	gene	0.72
ALS	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Als	inhibits	disease	0.65
GFAP	inhibits	gene	0.64
OXIDATIVE_STRESS	activates	pathway	0.64
INFLAMMATION	activates	pathway	0.64
APOPTOSIS	activates	pathway	0.64
MYELIN	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
MBP	inhibits	gene	0.60
GAP43	inhibits	gene	0.60
NEURON	activates	gene	0.60
MANF	inhibits	gene	0.60
AXON	activates	gene	0.60
SYN2A	inhibits	gene	0.60
ELAVL3	inhibits	gene	0.60
Neuron	activates	cell_type	0.60
TUBULIN	inhibits	gene	0.60
AND	activates	gene	0.60
GENES	inhibits	gene	0.60
NEUROTOXICITY	activates	gene	0.60
ROS	activates	gene	0.60
Neutrophil	activates	cell_type	0.60
Caspase	activates	protein	0.60
Tubulin	inhibits	protein	0.60
Raf	activates	protein	0.60
Rb	associated_with	protein	0.60
apoptosis pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
Spinal Cord	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (18)

Source	Relation	Type	Str
TUBULIN	inhibits	gene	0.60
SYN2A	inhibits	gene	0.60
ACHE	inhibits	gene	0.60
GAP43	inhibits	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MANF	inhibits	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
NEURON	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
MBP	inhibits	gene	0.60
ELAVL3	inhibits	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
GENES	inhibits	gene	0.60
MYELIN	activates	gene	0.60
GFAP	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found