protein

TYRO3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TYRO3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Tyro3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	TYRO3PROTEIN
Full Name	Tyro3
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the central nervous system, particularly in neurons, microglia, and [astrocytes](/enti
Subcellular Localization	Cell membrane, Endosomes Protein Family:** TAM Receptor Tyrosine Kinase Fam
Molecular Weight	140 kDa
UniProt ID	Search UniProt
GeneCards	TYRO3PROTEIN
Human Protein Atlas	TYRO3PROTEIN
Extracellular Domain	Contains two N-terminal immunoglobulin-like domains and two fibronectin type III repeats, responsible for ligand binding (Gas6, Protein S)
Transmembrane Domain	Single-pass membrane-spanning helix
Intracellular Domain	Contains the tyrosine kinase domain with activation loop and substrate binding sites
PI3K/AKT pathway	Major pro-survival signaling cascade
MAPK/ERK pathway	Regulates neuronal differentiation and plasticity
Associated Diseases	Aging, Diabetes, Ferroptosis, neuroinflammation
SciDEX Hypotheses	TYRO3-STAT1 Axis to Preserve Parvalbumin Interneur
KG Connections	18 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TYRO3PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Tyro3 Protein

protein · 793 words

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Pathway Diagram

graph TD
    TYRO3PROTEIN["TYRO3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TYRO3PROTEIN -->|"implicated_in"| neurodegeneration
    style TYRO3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TYRO3PROTEIN in their description or question text

No additional research found