Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UNC5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive review of UNC5A, a netrin receptor that mediates axon repulsion, functions as a dependence receptor, and is implicated in neurodevelopment and neurodegeneration.
| Gene Symbol | UNC5A |
| Full Name | UNC-5 Netrin Receptor A (UNC5H1) |
| Chromosome | 5q32 |
| Protein Type | Receptor |
| Function | is a transmembrane receptor that plays critical roles in axon guidance, neuronal migration, and cell survival during development [1]. |
| Primary Expression | Cortex, hippocampus, thalamus, spinal cord |
| Exons | 24 |
| UniProt ID | Q8IZJ3 |
| NCBI Gene ID | 9022 |
| Ensembl ID | ENSG00000163645 |
| OMIM | 607215 |
| GeneCards | UNC5A |
| Human Protein Atlas | UNC5A |
| Protein Class | Netrin receptor, Dependence receptor |
| Associated Diseases | neurodegeneration |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
UNC5A["UNC5A"]
style UNC5A fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
UNC5B["UNC5B"]
UNC5C["UNC5C"]
UNC5D["UNC5D"]
DCC["DCC"]
neurodegeneration["neurodegeneration"]
UNC5A -->|"regulates"| UNC5B
UNC5A -->|"regulates"| UNC5C
UNC5A -->|"regulates"| UNC5D
DCC -->|"regulates"| UNC5A
UNC5A -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class UNC5B gene
class UNC5C gene
class UNC5D gene
class DCC gene
class neurodegeneration disease| Source | Relation | Type | Str |
|---|---|---|---|
| DCC | regulates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||