Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DCC is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 42 entities in the SciDEX knowledge graph.
| Gene Symbol | DCC |
| Full Name | Deleted in Colorectal Cancer |
| Chromosome | 18q21.2 |
| Protein Type | Receptor |
| Function | DCC is a member of the immunoglobulin superfamily of cell adhesion molecules and functions as the primary receptor for the axon guidance molecule netrin-1. |
| Primary Expression | the developing and adult central nervous system, where it plays essential roles in neuronal axon guidance, cell migration, synapse formation, and syna |
| Amino Acids | 750 aa |
| Pathways | PI3K-AKT-mTOR signaling |
| UniProt ID | [Q9Y266](https://www.uniprot.org/uniprot/Q9Y266) |
| Ensembl ID | ENSG00000187323 |
| OMIM | 120470 |
| GeneCards | DCC |
| Human Protein Atlas | DCC |
| Extracellular Domain | 4 immunoglobulin (Ig) domains and 6 fibronectin type III (FNIII) repeats that mediate netrin-1 binding and cell adhesion |
| Transmembrane Domain | Single pass transmembrane helix |
| Associated Diseases | Als, Cancer |
| Interactions | KCNK2, CD44, FGF10, KCNH1, NCAM1, RGS1 |
| KG Connections | 83 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DCC["<b>DCC</b>"]
Als{"Als"}
DCC -->|"activates"| Als
Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
DCC -->|"activates"| Amyotrophic_Lateral_Sclerosis
Ms{"Ms"}
DCC -->|"activates"| Ms
Carcinoma{"Carcinoma"}
DCC -->|"inhibits"| Carcinoma
DCC -->|"inhibits"| Ms
Cancer{"Cancer"}
DCC -->|"inhibits"| Cancer
Tumor{"Tumor"}
DCC -->|"inhibits"| Tumor
GENES["GENES"]
DCC -->|"activates"| GENES
KCNK2["KCNK2"]
DCC -->|"inhibits"| KCNK2
CD44["CD44"]
DCC -->|"inhibits"| CD44
FGF10["FGF10"]
DCC -->|"inhibits"| FGF10
DLC1["DLC1"]
DCC -->|"associated with"| DLC1
EPHA4["EPHA4"]
EPHA4 -->|"activates"| DCC
CDKN2A["CDKN2A"]
CDKN2A -->|"associated with"| DCC
TLR4["TLR4"]
TLR4 -->|"inhibits"| DCC
CANCER["CANCER"]
CANCER -->|"inhibits"| DCC
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"inhibits"| DCC
TNC["TNC"]
TNC -->|"inhibits"| DCC
NTRK2["NTRK2"]
NTRK2 -->|"inhibits"| DCC
PAK1["PAK1"]
PAK1 -->|"inhibits"| DCC
WNT7A["WNT7A"]
WNT7A -->|"associated with"| DCC
LZTS1["LZTS1"]
LZTS1 -->|"associated with"| DCC
style DCC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Carcinoma | contributes_to | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| KCNK2 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| FGF10 | inhibits | gene | 0.60 |
| DLC1 | associated_with | gene | 0.60 |
| KCNH1 | inhibits | gene | 0.60 |
| NCAM1 | inhibits | gene | 0.60 |
| RGS1 | inhibits | gene | 0.60 |
| RAB27A | inhibits | gene | 0.60 |
| COL4A1 | associated_with | gene | 0.60 |
| BRCA1 | associated_with | gene | 0.60 |
| MYC | causes | gene | 0.60 |
| TRAF3 | regulates | gene | 0.60 |
| NGN2 | regulates | gene | 0.60 |
| MEF2C | regulates | gene | 0.60 |
| EPHA5 | regulates | gene | 0.60 |
| NLGN1 | associated_with | gene | 0.60 |
| ESR1 | regulates | gene | 0.60 |
| FOXP2 | regulates | gene | 0.60 |
| GRIA1 | regulates | gene | 0.60 |
| GRM8 | regulates | gene | 0.60 |
| NCAM1 | regulates | gene | 0.60 |
| PDE4B | regulates | gene | 0.60 |
| cancer | associated_with | disease | 0.60 |
| GENES | activates | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| P53 | associated_with | gene | 0.60 |
| RAS | causes | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Cell Cycle | causes | pathway | 0.60 |
| Differentiation | causes | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| AXON | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| App | regulates | protein | 0.60 |
| PS1 | inhibits | gene | 0.60 |
| PS1 | associated_with | gene | 0.60 |
| UNC5A | regulates | gene | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EPHA4 | activates | gene | 0.60 |
| CDKN2A | associated_with | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNC | inhibits | gene | 0.60 |
| NTRK2 | inhibits | gene | 0.60 |
| PAK1 | inhibits | gene | 0.60 |
| WNT7A | associated_with | gene | 0.60 |
| LZTS1 | associated_with | gene | 0.60 |
| PTEN | associated_with | gene | 0.60 |
| NGN1 | regulates | gene | 0.60 |
| NGN2 | regulates | gene | 0.60 |
| MEF2C | regulates | gene | 0.60 |
| EPHA5 | regulates | gene | 0.60 |
| NLGN1 | associated_with | gene | 0.60 |
| NCAM1 | regulates | gene | 0.60 |
| GRIA1 | regulates | gene | 0.60 |
| GRM8 | regulates | gene | 0.60 |
| ESR1 | regulates | gene | 0.60 |
| PDE4B | regulates | gene | 0.60 |
| FOXP2 | regulates | gene | 0.60 |
| CACNA1E | regulates | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| AKT | activates | gene | 0.55 |
| APOE | associated_with | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||