gene

DCC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections
0Hypotheses
0Analyses
50Outgoing
26Incoming

Summary

DCC is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 42 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolDCC
Full NameDeleted in Colorectal Cancer
Chromosome18q21.2
Protein TypeReceptor
FunctionDCC is a member of the immunoglobulin superfamily of cell adhesion molecules and functions as the primary receptor for the axon guidance molecule netrin-1.
Primary Expressionthe developing and adult central nervous system, where it plays essential roles in neuronal axon guidance, cell migration, synapse formation, and syna
Amino Acids750 aa
PathwaysPI3K-AKT-mTOR signaling
UniProt ID[Q9Y266](https://www.uniprot.org/uniprot/Q9Y266)
Ensembl IDENSG00000187323
OMIM120470
GeneCardsDCC
Human Protein AtlasDCC
Extracellular Domain4 immunoglobulin (Ig) domains and 6 fibronectin type III (FNIII) repeats that mediate netrin-1 binding and cell adhesion
Transmembrane DomainSingle pass transmembrane helix
Associated DiseasesAls, Cancer
InteractionsKCNK2, CD44, FGF10, KCNH1, NCAM1, RGS1
KG Connections83 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

DCC

gene · 2541 words

MACF1 — Microtubule-actin crosslinking factor 1

gene · 4087 words

MYO6 — Myosin VI

gene · 3211 words

Netrin Signaling Pathway in Neurodegeneration

mechanism · 3040 words

UNC5B — Netrin-1 Receptor

gene · 3019 words

TrkB Protein

protein · 2959 words

Pathway Diagram

graph TD
    DCC["<b>DCC</b>"]
    Als{"Als"}
    DCC -->|"activates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DCC -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    DCC -->|"activates"| Ms
    Carcinoma{"Carcinoma"}
    DCC -->|"inhibits"| Carcinoma
    DCC -->|"inhibits"| Ms
    Cancer{"Cancer"}
    DCC -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    DCC -->|"inhibits"| Tumor
    GENES["GENES"]
    DCC -->|"activates"| GENES
    KCNK2["KCNK2"]
    DCC -->|"inhibits"| KCNK2
    CD44["CD44"]
    DCC -->|"inhibits"| CD44
    FGF10["FGF10"]
    DCC -->|"inhibits"| FGF10
    DLC1["DLC1"]
    DCC -->|"associated with"| DLC1
    EPHA4["EPHA4"]
    EPHA4 -->|"activates"| DCC
    CDKN2A["CDKN2A"]
    CDKN2A -->|"associated with"| DCC
    TLR4["TLR4"]
    TLR4 -->|"inhibits"| DCC
    CANCER["CANCER"]
    CANCER -->|"inhibits"| DCC
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| DCC
    TNC["TNC"]
    TNC -->|"inhibits"| DCC
    NTRK2["NTRK2"]
    NTRK2 -->|"inhibits"| DCC
    PAK1["PAK1"]
    PAK1 -->|"inhibits"| DCC
    WNT7A["WNT7A"]
    WNT7A -->|"associated with"| DCC
    LZTS1["LZTS1"]
    LZTS1 -->|"associated with"| DCC
    style DCC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

TargetRelationTypeStr
Alsactivatesdisease0.65
Amyotrophic Lateral Sclerosisactivatesdisease0.65
Msactivatesdisease0.65
Carcinomainhibitsdisease0.65
Msinhibitsdisease0.65

Incoming (26)

SourceRelationTypeStr
EPHA4activatesgene0.60
CDKN2Aassociated_withgene0.60
TLR4inhibitsgene0.60
TNCinhibitsgene0.60
NTRK2inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found