gene

UNC5B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UNC5B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

47Outgoing

8Incoming

Summary

UNC5B: Netrin-1 receptor mediating axon guidance, blood-brain barrier integrity, angiogenesis, and dependence receptor-induced apoptosis in neurodegeneration

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🧬 Gene Info

Gene Symbol	UNC5B
Full Name	Netrin-1 Receptor
Chromosome	10q21.3
Protein Type	Receptor
Function	is a member of the UNC-5 family of netrin-1 receptors that functions as a dependence receptor, mediating both attractive and repulsive axon guidance in the developing nervous system.
Molecular Weight	105 kDa
Amino Acids	945 aa
Exons	21
UniProt ID	[Q9NSP8](https://www.uniprot.org/uniprot/Q9NSP8)
Ensembl ID	ENSG00000144868
GeneCards	UNC5B
Human Protein Atlas	UNC5B
UNC5B-long	The full-length receptor with all functional domains
UNC5B-short	Lacks portions of the intracellular domain, may act as a dominant-negative
Soluble variants	Secreted forms that may modulate netrin-1 signaling
Associated Diseases	AD, ALI, ARDS, ARM, Aging, Als
Interactions	APOE, APOPTOSIS, CANCER, P53, INFLAMMATION, LDL
KG Connections	55 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UNC5B["<b>UNC5B</b>"]
    Netrin_1["Netrin-1"]
    UNC5B -->|"binds"| Netrin_1
    autophagy["autophagy"]
    UNC5B -->|"regulates"| autophagy
    angiogenesis["angiogenesis"]
    UNC5B -->|"regulates"| angiogenesis
    neurite_complexity["neurite complexity"]
    UNC5B -->|"regulates"| neurite_complexity
    growth_cone["growth cone"]
    UNC5B -->|"regulates"| growth_cone
    bladder_cancer{"bladder cancer"}
    UNC5B -->|"associated with"| bladder_cancer
    bladder_cancer_recurrence["bladder cancer recurrence"]
    UNC5B -->|"decreases risk"| bladder_cancer_recurrence
    Cancer{"Cancer"}
    UNC5B -->|"therapeutic target"| Cancer
    Als{"Als"}
    UNC5B -->|"therapeutic target"| Als
    Carcinoma{"Carcinoma"}
    UNC5B -->|"therapeutic target"| Carcinoma
    Aging{"Aging"}
    UNC5B -->|"therapeutic target"| Aging
    Ms{"Ms"}
    UNC5B -->|"therapeutic target"| Ms
    Netrin_1 -->|"binds"| UNC5B
    UBQLN2["UBQLN2"]
    UBQLN2 -->|"interacts with"| UNC5B
    AND["AND"]
    AND -->|"activates"| UNC5B
    style UNC5B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

Target	Relation	Type	Str
Netrin-1	binds	protein	0.90
angiogenesis	regulates	biological_process	0.80
neurite complexity	regulates	phenotype	0.70
growth cone	regulates	entity	0.70
bladder cancer	associated_with	disease	0.70
bladder cancer recurrence	decreases_risk	phenotype	0.70
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Inflammation	activates	disease	0.65
APOE	activates	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Apoptosis	inhibits	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
P53	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
LDL	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
Stem Cell	therapeutic_target	cell_type	0.60
Epithelial	activates	cell_type	0.60
Ras	therapeutic_target	protein	0.60
UNC5C	regulates	gene	0.55
UNC5D	regulates	gene	0.55
Stem Cell	expressed_in	cell_type	0.55
ARDS	implicated_in	disease	0.50
breast cancer	implicated_in	disease	0.50
cancer	implicated_in	disease	0.50
carcinoma	implicated_in	disease	0.50
AD	implicated_in	disease	0.50
ALI	implicated_in	disease	0.50
Als	implicated_in	disease	0.50
ARM	implicated_in	disease	0.50
Aging	implicated_in	disease	0.50
Ms	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
SS	implicated_in	disease	0.50
NETRIN-1	activates	protein	0.50

Incoming (8)

Source	Relation	Type	Str
Netrin-1	binds	protein	0.90
UBQLN2	interacts_with	gene	0.70
AXON	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
RNA	activates	gene	0.60
DCC	regulates	gene	0.55
UNC5A	regulates	gene	0.55
late	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

UNC5B

Understanding Entity Pages

Summary

Wiki Pages (21)

UNC5B — Netrin-1 Receptor

UBQLN2 — Ubiquilin 2

Netrin Signaling Pathway in Neurodegeneration

UNC5A — UNC-5 Netrin Receptor A

Axon Guidance in 4R-Tauopathies

UNC5D

NTN3 Gene

NTN2 Gene

NTN3 Protein

NTN4 Gene

UNC-5B Protein

UNC-5A Protein

DCC Netrin 1 Receptor Protein

UNC-5D Protein

Netrin 2 Protein

UBQLN2 Protein (Ubiquilin-2)

UBQLN2 Protein