phenotype

ferroptosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ferroptosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6670Connections

8Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

ferroptosis is a phenotype associated with neurodegeneration research. Key relationships include: regulates, inhibits, activates. Associated with Alzheimer's disease, Huntington's disease, Parkinson's disease. Connected to 99 entities in the SciDEX knowledge graph.

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Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ferroptosis["ferroptosis"] -->|"causes"| myocardial_ischemia_reperfusio["myocardial ischemia-reperfusion injury"]
    ferroptosis["ferroptosis"] -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    ferroptosis["ferroptosis"] -->|"causes"| tumor_cells["tumor cells"]
    ferroptosis["ferroptosis"] -->|"contributes to"| osteoarthritis["osteoarthritis"]
    ferroptosis["ferroptosis"] -->|"regulates"| iron_metabolism["iron metabolism"]
    ferroptosis["ferroptosis"] -->|"regulates"| lipid_metabolism["lipid metabolism"]
    SLC7A11["SLC7A11"] -.->|"inhibits"| ferroptosis["ferroptosis"]
    lipid_peroxidation["lipid_peroxidation"] -->|"causes"| ferroptosis["ferroptosis"]
    GPX4["GPX4"] -.->|"inhibits"| ferroptosis["ferroptosis"]
    ferritinophagy["ferritinophagy"] -->|"associated"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2627)

Target	Relation	Type	Str
lipid peroxidation	causes	process	0.95
granulosa cells	causes	cell_type	0.90
renal injury	causes	disease	0.90
atherosclerosis	promotes	disease	0.90
unfolded protein response	crosstalk_with	pathway	0.90
macrophages	active_in	cell_type	0.90
pyroptosis	crosstalk_with	pathway	0.90
necroptosis	crosstalk_with	pathway	0.90
lipid metabolism	crosstalk_with	pathway	0.90
neurons	active_in	cell_type	0.90
microglia	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
Myocardial Infarction	contributes_to	disease	0.90
dopaminergic neuron	causes	cell_type	0.88
Parkinson's disease	promotes	disease	0.87
pancreatic cancer	promotes	disease	0.85
regulated cell death	involved_in	process	0.85
lipid peroxidation	mediates	process	0.85
ovarian reserve	contributes_to	phenotype	0.85
Acute Lung Injury	contributes_to	disease	0.85
granulosa cells	associated_with	cell_type	0.85
oxidative stress	mediates	process	0.85
Psoriasis	contributes_to	disease	0.85
myocardial ischemia-reperfusion injury	causes	disease	0.80
tumor cells	causes	cell_type	0.80
myocardial ischemia-reperfusion injury	associated_with	disease	0.80
acute kidney injury	associated_with	disease	0.80
colitis	promotes	disease	0.80
Contrast-Induced Nephropathy	causes	disease	0.80
chemo-resistance	inhibits	phenotype	0.80
ovarian reserve	associated_with	phenotype	0.80
necroinflammation	contributes_to	process	0.80
Alzheimer's disease	causes	disease	0.80
endothelial cells	active_in	cell_type	0.80
hippocampus	active_in	brain_region	0.80
Systemic Lupus Erythematosus	implicated_in	disease	0.75
Autosomal Dominant Polycystic Kidney Disease	implicated_in	disease	0.75
Depression	implicated_in	disease	0.75
α-synuclein neuronal death	causes (iron-dependent ferroptosis contributes to α-synucl)	disease	0.74
osteoarthritis	contributes_to	disease	0.71
iron metabolism	regulates	pathway	0.70
cysteine metabolism	regulates	pathway	0.70
neurodegeneration	causes	process	0.70
hemorrhagic transformation	causes	disease	0.70
carcinoma	associated_with	disease	0.70
white matter	active_in	brain_region	0.70
nucleus accumbens	active_in	brain_region	0.70
lipid metabolism	regulates	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
Parkinson's disease	associated_with	disease	0.70

Incoming (4043)

Source	Relation	Type	Str
SLC7A11	inhibits	gene	1.00
lipid_peroxidation	causes	phenotype	1.00
GPX4	inhibits	protein	1.00
Tim-AIII	promotes	drug	0.95
sorcin	inhibits	protein	0.95
copper	promotes	drug	0.95
Emodin	promotes	drug	0.95
NRF2	inhibits	gene	0.95
STING	promotes	protein	0.95
Ischemia/Reperfusion Injury	mediates	disease	0.95
iron	drives	compound	0.95
Cadmium	associated_with	compound	0.95
iron overload	drives	phenotype	0.95
PCK2	promotes	protein	0.93
Emodin	prevents	drug	0.93
SLC7A11-ALOX12	promotes	pathway	0.92
TP53	regulates	gene	0.92
SLC13A3	promotes	gene	0.92
Lnk-Cbl-Hnrnpa2B1-Gpx4	mediates	pathway	0.92
copper deficiency	promotes	phenotype	0.92
ferritinophagy	associated_with	pathway	0.90
lipophagy	associated_with	pathway	0.90
sorafenib	activates	drug	0.90
erastin	activates	drug	0.90
APOE	protects_against	gene	0.90
substance P	inhibits	protein	0.90
ZnONPs	causes	drug	0.90
ATG5	protects_against	gene	0.90
ferritinophagy	causes	pathway	0.90
Nuciferine	protects_against	drug	0.90
gastrodin	inhibits	drug	0.90
STING	causes	protein	0.90
BMAL1 degradation	associated_with	phenotype	0.90
RB1CC1 Ser537 phosphorylation	activates	phenotype	0.90
Rehmannioside A	inhibits	drug	0.90
STING	activates	protein	0.90
iron overload	activates	phenotype	0.90
GPX4	prevents	protein	0.90
ALDH1A1	regulates	protein	0.90
celastrol	promotes	drug	0.90
Hesperetin	inhibits	drug	0.90
NRF2-SLC7A11 pathway	inhibits	pathway	0.90
NRF2	prevents	protein	0.90
PARKIN	prevents	protein	0.90
TP53	promotes	gene	0.90
SLC7A11-ALOX12	activates	pathway	0.90
ferritinophagy	promotes	process	0.90
SLC7A11	participates_in	gene	0.90
GPX4	participates_in	gene	0.90
stroke	involves	disease	0.90

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.662	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Ferroptosis Inhibition for α-Synuclein Neuroprotection	0.548	neurodegeneration	Gene expression changes in aging mouse b
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.485	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulati [PMID:40993092]	Jiang H, Hu W, Yuan L	Tohoku J Exp Med	2026
GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051]	Yang M, Bian F, Feng X, Li L, Huang H et	Mol Ther	2026
Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530]	Liu J, Cai X, Lin J, Zhang Z, Zhou Q et	Cell	2026
Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398]	Gromadzka G, Tarnacka B, Cieślik M	Int J Mol Sci	2026
Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903]	Tuo QZ, Bush AI, Lei P	Mol Psychiatry	2026
Fin(e)-tuning ferroptosis. [PMID:41576911]	Szylo KJ, Dixon SJ	Mol Cell	2026
GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525]	Liu G, Wang Y, Huang H, Wang J, Yang J e	Cell Mol Immunol	2026
A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096]	Xia Z, Yang X, Samovich SN, Tyurina YY,	Cell	2026
The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697]	Park WH	Pharmacol Res	2026
Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060]	Song C, Liu Z, Tang J, Huang Y	Neuropsychiatr Dis Treat	2026
Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143]	Chen X	Trends Mol Med	2026
4-Octyl itaconate attenuates radiation-induced intestinal injury associated with [PMID:41936917]	Zhang S, Yue T, Jin P, Zhang X, Huo Q et	Free Radic Biol Med	2026
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026
Co-Delivery of Ferrostatin-1 and M2 Macrophage-Derived Exosomal Signals via Engi [PMID:41944411]	Hao W, Sun N, Xue R, Chang J, Pang X et	ACS Appl Mater Interfaces	2026
Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell [PMID:41945797]	Zhang Y, Wang X, Wu Y, Liu L, Nuerlan G	Adv Sci (Weinh)	2026
Ferroptosis-related mechanisms in prion diseases provide insights into neurodege [PMID:41945998]	Zayed M, Tayara H, Jeong BH	Redox Biol	2026
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026
Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243]	Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L	Stem Cell Res Ther	2026
NOX4 mediates ferroptosis through oxidative stress in diabetic keratopathy. [PMID:41951167]	Wang X, Wang Y, Zhao X, Yu X, Qu Y et al	Exp Eye Res	2026
Targeting NDUFS4 Disrupts Oxidative Phosphorylation and Induces Ferroptosis in O [PMID:41954274]	Schaaf ZA, Ning S, Leslie AR, Sharifi M,	Mol Cancer Ther	2026

ferroptosis

Understanding Entity Pages

Summary

Wiki Pages (21)

Ferroptosis-Sensitive Neurons

cbs-psp-daily-action-plan

Novel Therapy Index

Alzheimer's Disease Mechanism Index

Therapeutics

Alzheimer's Disease

Pathway Diagram

Outgoing (2627)

Incoming (4043)

Targeting Hypotheses (8)

Mentioning Analyses (3)

What determines the GPX4/ACSL4 balance that switches microglia from protective t

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Related Papers (20)

ferroptosis

Understanding Entity Pages

Summary

Wiki Pages (21)

Ferroptosis-Sensitive Neurons

cbs-psp-daily-action-plan

Novel Therapy Index

Alzheimer's Disease Mechanism Index

Therapeutics

Alzheimer's Disease

oxidative-stress-comparison

Vitamin D Signaling Pathway in Neurodegeneration

rankings

protective-strategies-cbs-psp

Coenzyme Q10 for Neurodegeneration

substantia-nigra

deferiprone-neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Ferroptosis in Alzheimer's Disease

Excitotoxicity in Neurodegeneration

Neuronal Ceroid Lipofuscinosis (NCL)

metal-ion-synuclein-mitochondria-axis-parkinsons

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Gut-Brain Axis in Neurodegeneration

Pathway Diagram

Outgoing (2627)

Incoming (4043)

Targeting Hypotheses (8)

Mentioning Analyses (3)

What determines the GPX4/ACSL4 balance that switches microglia from protective t

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Related Papers (20)