protein

VPS29PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS29PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

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Summary

Vacuolar Protein Sorting Associated Protein 29 plays an important role in the study of neurodegenerative diseases.

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🔬 Protein Info

Gene Symbol	VPS29PROTEIN
Function	is a core subunit of the retromer complex, a crucial protein complex involved in retrograde transport from endosomes to the trans-Golgi network (TGN) and the cell surface.
Subcellular Localization	** Endosomes, trans-Golgi network, cytoplasm ``` ## Structure VPS29 is a 182-a
Molecular Weight	18 kDa
GeneCards	VPS29PROTEIN
Human Protein Atlas	VPS29PROTEIN
N-terminal domain	Flexible region involved in protein interactions
Central scaffold domain	Forms the core structural framework
C-terminal region	Mediates interaction with VPS35
VPS26	Cargo recognition subunit (VPS26A or VPS26B)
VPS35	Large scaffolding subunit
VPS29	Structural scaffold and regulatory subunit
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, App, GENES, GENETIC MODIFIERS
KG Connections	43 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Vacuolar protein sorting-associated protein 29

protein · 1114 words

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Pathway Diagram

graph TD
    VPS29PROTEIN["VPS29PROTEIN"]
    neurodegeneration["neurodegeneration"]
    VPS29PROTEIN -->|"implicated_in"| neurodegeneration
    style VPS29PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning VPS29PROTEIN in their description or question text

No additional research found