Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS33B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VPS33B encodes a lysosomal trafficking protein critical for autophagosome-lysosome fusion, with roles in neurodegenerative diseases including ARC syndrome, Alzheimer's, and Parkinson's
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| Gene Symbol | VPS33B |
| Full Name | Vacuolar Protein Sorting 33 Homolog B |
| Chromosome | 15q26.3 |
| Function | VPS33B is predominantly expressed in the brain and neurons, while VPS33A is more broadly expressed in other tissues. |
| Primary Expression | the brain and neurons, while VPS33A is more broadly expressed in other tissues |
| Molecular Weight | 110 kDa |
| Amino Acids | 517 aa |
| UniProt ID | [Q9H0M0](https://www.uniprot.org/uniprot/Q9H0M0) |
| Ensembl ID | ENSG00000011201 |
| OMIM | 613299 |
| GeneCards | VPS33B |
| Human Protein Atlas | VPS33B |
| SNARE Proteins | VPS33B regulates SNARE complex assembly (STX17, SNAP29, VAMP8) for membrane fusion |
| TREM2 | The microglial receptor implicated in Alzheimer's disease operates in pathways overlapping with VPS33B-mediated lysosomal function [@yang2019] |
| LAMP1/LAMP2 | Lysosomal-associated membrane proteins that cooperate with HOPS in lysosomal fusion |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VPS33B["VPS33B"]
neurodegeneration["neurodegeneration"]
VPS33B -->|"implicated_in"| neurodegeneration
style VPS33B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| genes-vps33b | linked_to | wiki | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning VPS33B in their description or question text
No additional research found