| Gene Symbol | VPS33B |
| Full Name | Vacuolar Protein Sorting 33 Homolog B |
| Chromosome | 15q26.3 |
| Function | VPS33B is predominantly expressed in the brain and neurons, while VPS33A is more broadly expressed in other tissues. |
| Primary Expression | the brain and neurons, while VPS33A is more broadly expressed in other tissues |
| Molecular Weight | 110 kDa |
| Amino Acids | 517 aa |
| UniProt ID | [Q9H0M0](https://www.uniprot.org/uniprot/Q9H0M0) |
| Ensembl ID | ENSG00000011201 |
| OMIM | 613299 |
| GeneCards | VPS33B |
| Human Protein Atlas | VPS33B |
| SNARE Proteins | VPS33B regulates SNARE complex assembly (STX17, SNAP29, VAMP8) for membrane fusion |
| TREM2 | The microglial receptor implicated in Alzheimer's disease operates in pathways overlapping with VPS33B-mediated lysosomal function [@yang2019] |
| LAMP1/LAMP2 | Lysosomal-associated membrane proteins that cooperate with HOPS in lysosomal fusion |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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