gene

WNT8A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Wnt Family Member 8A - secreted signaling protein involved in canonical Wnt/β-catenin pathway, dopaminergic neuron specification, and neurodevelopment

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🧬 Gene Info

Gene Symbol	WNT8A
Aliases	Wnt Family Member 8A
Function	Like all Wnt proteins, WNT8A contains a conserved Wnt1 domain (SMART00097) that is essential for receptor binding and signaling activity.
Primary Expression	kidney, heart, intestine during development
Amino Acids	349 aa
Pathways	WNT, Wnt, Wnt signaling, Wnt pathway
Ensembl ID	ENSG00000068972
GeneCards	WNT8A
Human Protein Atlas	WNT8A
N-terminal signal peptide	Directs secretion via the secretory pathway
Wnt domain	Highly conserved signaling region with multiple cysteine residues forming disulfide bonds
Lipid modification	Palmitoylation at a conserved cysteine is required for secretion and activity
Glycosylation	N-linked carbohydrates enhance stability and solubility
Planar cell polarity (PCP) pathway	Through FZD receptors, activates DVL and small GTPases
Wnt/Ca²⁺ pathway	Through FZD and Ror receptors, increases intracellular calcium
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WNT8A Gene

gene · 1543 words

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Pathway Diagram

graph TD
    WNT8A["WNT8A"]
    neurodegeneration["neurodegeneration"]
    WNT8A -->|"implicated_in"| neurodegeneration
    style WNT8A fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning WNT8A in their description or question text

No additional research found