gene

ZDHHC9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZDHHC9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

ZDHHC9 (Zinc Finger DHHC-Type Containing 9) - palmitoyltransferase involved in protein S-acylation (palmitoylation), synaptic protein modification, neuronal signaling, and implicated in X-linked intellectual disability, Alzheimer's disease, and Parkinson's disease through lipid modification pathways

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🧬 Gene Info

Gene Symbol	ZDHHC9
Aliases	Zinc Finger DHHC-Type Containing 9
Chromosome	Xq26.1
Protein Type	Transferase
Primary Expression	Highest in brain, particularly cortex and hippocampus
Molecular Weight	52 kDa
Amino Acids	458 aa
Pathways	Immune Response
UniProt ID	Q9Y278
NCBI Gene ID	51014
Ensembl ID	ENSG00000133240
OMIM	300503
GeneCards	ZDHHC9
Human Protein Atlas	ZDHHC9
Associated Diseases	neurodegeneration
Interactions	NDP52, TBK1
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ZDHHC9 — AlphaFold Q9Y278 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ZDHHC9 Gene (Zinc Finger DHHC-Type Containing 9)

gene · 2051 words

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Pathway Diagram

graph TD
    ZDHHC9["ZDHHC9"]
    Als{"Als"}
    ZDHHC9 -->|"activates"| Als
    Ms{"Ms"}
    ZDHHC9 -->|"activates"| Ms
    NDP52["NDP52"]
    ZDHHC9 -->|"activates"| NDP52
    TBK1["TBK1"]
    ZDHHC9 -->|"activates"| TBK1
    Immune_Response(["Immune Response"])
    ZDHHC9 -->|"activates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    ZDHHC9 -->|"implicated in"| neurodegeneration
    style ZDHHC9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Als	activates	disease	0.65
Ms	activates	disease	0.65
Immune Response	activates	pathway	0.60
NDP52	activates	gene	0.60
TBK1	activates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ZDHHC9 in their description or question text

No additional research found