gene

NDP52

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDP52: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1151Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NDP52 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 559 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDP52
Full Name	NDP52
Chromosome	21q22.12.
Protein Type	Gene
Function	Mitophagy: NDP52 recognizes ubiquitinated damaged mitochondria and recruits LC3-positive autophagosomes through its LIR domain
Primary Expression	various tissues with particularly high expression in immune cells and neurons
Amino Acids	452 aa
Exons	11
Pathways	Adaptive Immunity, Autophagy, Complement, Immune Response, Innate Immunity
NCBI Gene ID	Search NCBI
GeneCards	NDP52
Human Protein Atlas	NDP52
Associated Diseases	AD, ALI, ALS, AMI, Alzheimer
Known Drugs/Compounds	dimethyl fumarate, EGCG, rapamycin
Interactions	TAX1BP1, FUS, HIF1A, MAP1LC3B, GBA, FUNDC1
KG Connections	1151 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NDP52["NDP52"] -->|"recruits"| ULK1["ULK1"]
    NDP52["NDP52"] -->|"activates"| ULK1_1["ULK1"]
    NDP52["NDP52"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    NDP52["NDP52"] -->|"interacts"| Dementia["Dementia"]
    NDP52["NDP52"] -->|"interacts"| Als["Als"]
    NDP52["NDP52"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    PINK1["PINK1"] -->|"recruits"| NDP52["NDP52"]
    TBK1["TBK1"] -->|"facilitates"| NDP52["NDP52"]
    ACTB["ACTB"] -->|"interacts"| NDP52["NDP52"]
    OPTN["OPTN"] -->|"interacts"| NDP52["NDP52"]
    style NDP52 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (701)

Target	Relation	Type	Str
Als	interacts_with	disease	0.95
Als	regulates	disease	0.95
selective autophagy	participates_in	pathway	0.90
AUTOPHAGY	regulates	gene	0.90
Mitophagy	mediates	process	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
P62	activates	gene	0.90
UBIQUITIN	interacts_with	gene	0.90
OPTN	activates	gene	0.90
UBIQUITIN	activates	gene	0.90
Autophagy	interacts_with	pathway	0.90
Autophagy	activates	pathway	0.90
Mitophagy	regulates	pathway	0.90
Damaged Organelles	targets	phenotype	0.85
Damaged Organelle Clearance	involved_in	process	0.85
Intracellular Pathogen Clearance	involved_in	process	0.85
Selective Autophagy	involved_in	process	0.85
FIP200	binds	protein	0.85
PINK1/Parkin signaling pathway	interacts_with	pathway	0.85
FIP200	interacts_with	protein	0.84
STING	regulates	protein	0.80
nucleocapsid protein	interacts_with	protein	0.80
ULK1	regulates	gene	0.80
LC3B	interacts_with	protein	0.80
neural stem cells	activates	cell_type	0.80
P62	interacts_with	gene	0.80
OPTN	interacts_with	gene	0.80
Autophagy	associated_with	pathway	0.80
MITOCHONDRIA	regulates	gene	0.80
Cancer	regulates	disease	0.75
Infection	regulates	disease	0.75
MITOPHAGY	activates	pathway	0.74
ULK1	recruits	protein	0.72
ULK1	activates	protein	0.72
TAX1BP1	interacts_with	gene	0.70
LC3	interacts_with	gene	0.70
CALCOCO2	interacts_with	gene	0.70
STING1	interacts_with	gene	0.70
NBR1	interacts_with	gene	0.70
P62	associated_with	gene	0.70
NBR1	associated_with	gene	0.70
selective autophagy	regulates	process	0.70
xenophagy	regulates	process	0.70
aggrephagy	regulates	process	0.70
autophagy	regulates	process	0.70
ULK1	interacts_with	gene	0.70
LC3	activates	gene	0.70
STING	activates	gene	0.70
CGAS	regulates	gene	0.70
MTOR	activates	gene	0.70

Incoming (450)

Source	Relation	Type	Str
NAP1	promotes	protein	0.90
BEX2	interacts_with	protein	0.90
AUTOPHAGY	interacts_with	gene	0.90
AUTOPHAGY	activates	gene	0.90
TBK1	modulates	protein	0.85
BECN1	regulates	gene	0.80
NBR1	regulates	gene	0.80
ATG	regulates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
PINK1	recruits	protein	0.72
PTEN	interacts_with	gene	0.70
PINK1	activates	gene	0.70
PINK1	interacts_with	gene	0.70
CALCOCO2	encodes	gene	0.70
G3BP1	regulates	gene	0.70
FIP200	regulates	gene	0.70
EGCG	activates	drug	0.70
MITOPHAGY	activates	gene	0.70
MITOPHAGY	regulates	gene	0.70
MAP1LC3	activates	gene	0.70
ALS	regulates	gene	0.70
MAP1LC3	regulates	gene	0.70
ATG	activates	gene	0.70
AMPK	regulates	gene	0.70
GFP	regulates	gene	0.70
ACTB	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
SMCR8	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
TOLLIP	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NDP52

Understanding Entity Pages

Summary

Wiki Pages (21)

NDP52 Gene

cbs-psp-daily-action-plan

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Mitophagy Pathway in Neurodegeneration

Sulforaphane and Nrf2 Activation for Neuroprotection

mitophagy-defect

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Mitophagy Pathway in Neurodegeneration

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

Mitochondria in Neurodegeneration

pink1-parkin-mitophagy-pd-causal-chain

Urolithin A for Neurodegeneration

autophagy-lysosome-dysfunction

Lysosomal Dysfunction in Progressive Supranuclear Palsy

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

Mitochondrial Dysfunction Dopaminergic Neurons

VPS13C Protein

Neural Circuits in Progressive Supranuclear Palsy