gene

NDP52

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDP52: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1121Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

NDP52 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 559 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NDP52
Chromosome	21q22.12.
Protein Type	Gene
Function	Mitophagy: NDP52 recognizes ubiquitinated damaged mitochondria and recruits LC3-positive autophagosomes through its LIR domain
Primary Expression	various tissues with particularly high expression in immune cells and neurons
Amino Acids	452 aa
Exons	11
Pathways	Adaptive Immunity, Autophagy, Complement, Immune Response, Innate Immunity
GeneCards	NDP52
Human Protein Atlas	NDP52
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	dimethyl fumarate, EGCG, rapamycin
Interactions	ABCD3, ABP, ACAT1, ACTB, Actin, AIFM1
KG Connections	1120 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NDP52 Gene

gene · 825 words

→

NDP52 Protein

protein · 776 words

→

Pathway Diagram

graph TD
    NDP52["NDP52"] -->|"recruits"| ULK1["ULK1"]
    NDP52["NDP52"] -->|"activates"| ULK1_1["ULK1"]
    NDP52["NDP52"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    NDP52["NDP52"] -->|"interacts"| Dementia["Dementia"]
    NDP52["NDP52"] -->|"interacts"| Als["Als"]
    NDP52["NDP52"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    PINK1["PINK1"] -->|"recruits"| NDP52["NDP52"]
    TBK1["TBK1"] -->|"facilitates"| NDP52["NDP52"]
    ACTB["ACTB"] -->|"interacts"| NDP52["NDP52"]
    OPTN["OPTN"] -->|"interacts"| NDP52["NDP52"]
    style NDP52 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (684)

Target	Relation	Type	Str
NDP52	encodes	protein	0.00
Als	regulates	disease	0.95
Als	interacts_with	disease	0.95
AUTOPHAGY	regulates	gene	0.90
Mitophagy	mediates	process	0.90
selective autophagy	participates_in	pathway	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
damaged mitochondria	recruits	process	0.90
Autophagy	activates	pathway	0.90
P62	activates	gene	0.90
UBIQUITIN	interacts_with	gene	0.90
OPTN	activates	gene	0.90
UBIQUITIN	activates	gene	0.90
Autophagy	interacts_with	pathway	0.90
Mitophagy	regulates	pathway	0.90
PINK1/Parkin signaling pathway	interacts_with	pathway	0.85
Selective Autophagy	involved_in	process	0.85
Damaged Organelles	targets	phenotype	0.85
Intracellular Pathogen Clearance	involved_in	process	0.85
Damaged Organelle Clearance	involved_in	process	0.85
FIP200	associated_with	protein	0.85
FIP200	interacts_with	protein	0.84
nucleocapsid protein	interacts_with	protein	0.80
STING	regulates	protein	0.80
LC3B	interacts_with	protein	0.80
neural stem cells	activates	cell_type	0.80
ULK1	regulates	gene	0.80
OPTN	interacts_with	gene	0.80
Autophagy	associated_with	pathway	0.80
P62	interacts_with	gene	0.80
MITOCHONDRIA	regulates	gene	0.80
Infection	regulates	disease	0.75
Cancer	regulates	disease	0.75
MITOPHAGY	activates	pathway	0.74
ULK1	associated_with	protein	0.72
ULK1	activates	protein	0.72
Nf-Κb	regulates	pathway	0.70
TAX1BP1	interacts_with	gene	0.70
LC3	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
MITOCHONDRIA	activates	gene	0.70
Innate Immunity	regulates	pathway	0.70
MITOCHONDRIA	interacts_with	gene	0.70
mitophagy	regulates	process	0.70
inflammation	regulates	process	0.70
TRIM21	interacts_with	gene	0.70
aggrephagy	regulates	process	0.70
selective autophagy	regulates	process	0.70
ULK1	interacts_with	gene	0.70
Parkinson's disease	activates	disease	0.70

Incoming (437)

Source	Relation	Type	Str
NDP52	encodes	gene	0.00
NAP1	promotes	protein	0.90
BEX2	interacts_with	protein	0.90
AUTOPHAGY	activates	gene	0.90
AUTOPHAGY	interacts_with	gene	0.90
TBK1	associated_with	protein	0.85
ATG	regulates	gene	0.80
BECN1	regulates	gene	0.80
NBR1	regulates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
PINK1	recruits	protein	0.72
PINK1	activates	gene	0.70
MITOPHAGY	regulates	gene	0.70
CALCOCO2	encodes	gene	0.70
PTEN	interacts_with	gene	0.70
PINK1	interacts_with	gene	0.70
AMPK	regulates	gene	0.70
K63-ubiquitin chains	activates	pathway	0.70
MAP1LC3	activates	gene	0.70
FIP200	regulates	gene	0.70
ALS	regulates	gene	0.70
MAP1LC3	regulates	gene	0.70
ATG	activates	gene	0.70
GFP	regulates	gene	0.70
EGCG	activates	drug	0.70
MITOPHAGY	activates	gene	0.70
G3BP1	regulates	gene	0.70
GBA	interacts_with	gene	0.60
P62	activates	gene	0.60
WIPI1	interacts_with	gene	0.60
ATG5	inhibits	gene	0.60
IRF1	inhibits	gene	0.60
CALCOCO2	regulates	gene	0.60
DISC1	activates	entity	0.60
PARKIN	regulates	gene	0.60
P62	regulates	gene	0.60
OPTN	regulates	gene	0.60
PINK1	regulates	gene	0.60
AKT	activates	gene	0.60
DNM1L	activates	entity	0.60
BCL2L13	interacts_with	gene	0.60
TARDBP	degrades	gene	0.60
HNRNPK	degrades	gene	0.60
PTBP1	degrades	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
MAVS	regulates	gene	0.60
ACTB	regulates	gene	0.60
FUS	regulates	gene	0.60
NBR1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle	0.772	neurodegeneration	How do different organelle-specific auto

Mentioning Analyses (2)

Scientific analyses that reference this entity

How do different organelle-specific autophagy pathways coordinate during neurode

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.772

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.730

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899]	Merlo, Cuchillo-Ibañez, Parlato, Ra	Neural plasticity	2018
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
DNA Damage, Neurodegeneration, and Synaptic Plasticity. [PMID:27313899]	Unknown	Neural Plast	2016
Neurodegeneration. [PMID:12938729]	Burgunder	IUBMB life	2004
Neurodegeneration. [PMID:12938729]	Unknown	IUBMB Life	2003

Debates (2)

Multi-agent debates referencing this entity

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu

closed · Rounds: 4 · Score: 0.79 · 2026-04-21

The abstract mentions multiple organelles synchronously present structural deran

closed · Rounds: 4 · Score: 0.80 · 2026-04-21

Related Research

Hypotheses and analyses mentioning NDP52 in their description or question text

No additional research found