Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about alpha-synuclein aggregates: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| ESCRT-III | inhibits | protein | 0.98 |
| Parkinson's Disease | contributes_to | disease | 0.95 |
| Parkinson's Disease Progression | contributes_to | process | 0.93 |
| KV1.3 | upregulates | gene | 0.90 |
| ESCRT-III | degrades | protein | 0.90 |
| Mitophagy | activates | process | 0.90 |
| Microglial Activation | causes | process | 0.90 |
| Mitochondrial Depolarization | causes | process | 0.90 |
| Cardiolipin Externalization | associated_with | process | 0.90 |
| Mitochondria | interacts_with | cell_type | 0.90 |
| Kii ALS/PDC | biomarker_for | disease | 0.85 |
| glucocerebrosidase dysfunction | causes | phenotype | 0.70 |
| neuronal mitochondria fragmentation | promotes | process | 0.70 |
| Nigrostriatal Dopaminergic Neurodegeneration | associated_with | process | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S | 0.822 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.571
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
| Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's [PMID:37029500] | Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH, | Aging cell | 2023 | 0 |
| Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like [PMID:36288697] | Li S, Fang Y, Zhang Y, Song M, Zhang X, | Cell reports | 2022 | 0 |
| Biomarker of Neuroinflammation in Parkinson's Disease. [PMID:35456966] | Liu TW, Chen CM, Chang KH | Int J Mol Sci | 2022 | 0 |
| NLRP3 inflammasome activation drives tau pathology. [PMID:31748742] | ["Ising C", "Venegas C", "Zhang S", "Sch | Nature | 2019 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.89 · 2026-04-10
Hypotheses and analyses mentioning alpha-synuclein aggregates in their description or question text
No additional research found