Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ESCRT-III: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ESCRT |
| Pathways | Autophagy |
| GeneCards | ESCRT |
| Human Protein Atlas | ESCRT |
| Associated Diseases | SNCA, CHMP2B, CHMP4B, CHMP6 |
| Interactions | VPS4, VPS4A, CHMP2B, CHMP2A, CHMP3, CHMP4B |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ESCRT_III["ESCRT-III"] -->|"involved in"| Endolysosome_Membrane_Repair["Endolysosome Membrane Repair"]
style Endolysosome_Membrane_Repair fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
ESCRT_III["ESCRT-III"] -.->|"inhibits"| __Synuclein["alpha-Synuclein"]
style __Synuclein fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
ALPHA_SYNUCLEIN_AGGREGATES["ALPHA-SYNUCLEIN AGGREGATES"] -.->|"inhibits"| ESCRT_III["ESCRT-III"]
style ALPHA_SYNUCLEIN_AGGREGATES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
__Synuclein_Aggregates["alpha-Synuclein Aggregates"] -.->|"inhibits"| ESCRT_III["ESCRT-III"]
style __Synuclein_Aggregates fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
SNCA["SNCA"] -->|"interacts"| ESCRT_III["ESCRT-III"]
style SNCA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Collateral_Degradation["Collateral Degradation"] -->|"degrades"| ESCRT_III["ESCRT-III"]
style Collateral_Degradation fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
MAPT["MAPT"] -->|"disrupts"| ESCRT_III["ESCRT-III"]
style MAPT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style ESCRT_III fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | involved_in | pathway | 0.90 |
| Endolysosome Membrane Repair | involved_in | process | 0.85 |
| Autophagosome-Lysosome Fusion | regulates | process | 0.85 |
| α-Synuclein | inhibits | protein | 0.80 |
| DAM microglia | expressed_in | cell_type | 0.55 |
| neurodegeneration | activates | disease | 0.55 |
| neurodegeneration | protects_against | disease | 0.55 |
| VPS4 | interacts_with | gene | 0.55 |
| VPS4A | interacts_with | gene | 0.55 |
| tauopathy | regulates | disease | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALPHA-SYNUCLEIN AGGREGATES | inhibits | protein | 0.98 |
| α-Synuclein Aggregates | inhibits | protein | 0.95 |
| α-Synuclein Aggregates | interacts_with | protein | 0.90 |
| ALPHA-SYNUCLEIN AGGREGATES | degrades | protein | 0.90 |
| SNCA | interacts_with | protein | 0.90 |
| SNCA | associated_with | protein | 0.90 |
| Collateral Degradation | degrades | mechanism | 0.90 |
| α-Synuclein Aggregates | binds | protein | 0.85 |
| CHMP2B | interacts_with | protein | 0.85 |
| SNCA | inhibits | gene | 0.80 |
| CHMP4B | involved_in | protein | 0.60 |
| CHMP2B | regulates | gene | 0.55 |
| CHMP2B | associated_with | gene | 0.55 |
| CHMP4B | associated_with | gene | 0.55 |
| CHMP6 | associated_with | gene | 0.55 |
| CHMP2B | activates | gene | 0.55 |
| CHMP2A | interacts_with | gene | 0.55 |
| CHMP3 | interacts_with | gene | 0.55 |
| CHMP4B | interacts_with | gene | 0.55 |
| CHMP6 | interacts_with | gene | 0.55 |
| CHMP4B | causes | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||