concept

KV1.3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KV1.3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

0Analyses

31Outgoing

13Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	KV1.3
Key Genes/Proteins	Alpha-Synuclein, FYN
Related Diseases	Parkinson's Disease, Parkinson'S Disease, Melanoma, Als, Cancer

Wiki Pages (14)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    KV1_3["KV1.3"]
    KV1_3 -->|"modulates"| Neuroinflammation["Neuroinflammation"]
    KV1_3 -->|"modulates"| Neurodegeneration["Neurodegeneration"]
    KV1_3 -->|"expressed in"| Microglia["Microglia"]
    KV1_3 -->|"involved_in"| Parkinson_s_Disease["Parkinson's Disease"]
    KV1_3 -->|"contributes to"| Microglial_Activation["Microglial Activation"]
    KV1_3 -->|"activates"| neuroinflammation["neuroinflammation"]
    KV1_3 -->|"inhibits"| Melanoma["Melanoma"]
    KV1_3 -->|"inhibits"| Als["Als"]
    Alpha_Synuclein_Aggregates["Alpha-Synuclein Aggregates"] -->|"upregulates"| KV1_3
    FYN["FYN"] -->|"upregulates"| KV1_3
    SNCA["SNCA"] -->|"activates"| KV1_3
    PAP_1["PAP-1"] -->|"inhibits"| KV1_3
    AND["AND"] -->|"inhibits"| KV1_3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| KV1_3

Outgoing (33)

Target	Relation	Type	Str
Neuroinflammation	modulates	process	0.95
Neurodegeneration	modulates	process	0.95
Microglia	expressed_in	cell_type	0.90
Parkinson's Disease	involved_in	disease	0.90
Parkinson'S Disease	involved_in	disease	0.90
Microglial Activation	contributes_to	process	0.85
Microglial Activation	modulates	process	0.85
Melanoma	inhibits	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Depression	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
STAT3	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
P53	inhibits	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
DEPRESSION	activates	gene	0.60
DEMENTIA	activates	gene	0.60
PARKINSON	activates	gene	0.60
AND	activates	gene	0.60
FYN	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
Alpha-Synuclein Aggregates	upregulates	compound	0.90
Alpha-Synuclein	upregulates	protein	0.90
FYN	upregulates	gene	0.85
FYN	modulates	gene	0.85
FYN	phosphorylates	protein	0.80
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
FYN	activates	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KV1.3

Understanding Entity Pages

Wiki Pages (14)

ion-channel-dysfunction-disease-comparison

potassium-channel-openers-parkinsons

KCNAB3 — Potassium Voltage-Gated Channel Subfamily A Member Beta 3

Neuronal Hyperexcitability in Neurodegeneration

KCNE3 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 3)

Ion Channel Dysfunction in 4R-Tauopathies

Primed Microglia

KCNE4 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4)

KCNA1 Gene

KCNA2 Gene

KCNA2 Protein

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase