Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Mitophagy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Mitophagy is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Acute Kidney Injury, Aging. Connected to 1567 entities in the SciDEX knowledge graph.
| Name | Mitophagy |
| Key Genes/Proteins | PARKIN, PINK1, BNIP3, OPTN, PTEN, MTOR |
| Related Diseases | Als, Cancer, Aging |
| Linked Hypotheses | 5 hypotheses |
Knowledge base pages for this entity
graph TD
CAT["CAT"] -->|"interacts"| Mitophagy["Mitophagy"]
OPTN["OPTN"] -->|"interacts"| Mitophagy["Mitophagy"]
DNM1L["DNM1L"] -->|"interacts"| Mitophagy["Mitophagy"]
CANX["CANX"] -->|"interacts"| Mitophagy["Mitophagy"]
style Mitophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Organelle Quality Control | involved_in | process | 0.95 |
| Cochlear Hair Cells | protects_against | cell_type | 0.95 |
| Neuronal Survival | associated_with | phenotype | 0.95 |
| Intervertebral Disc Degeneration | involved_in | disease | 0.95 |
| Osteoarthritis | involved_in | disease | 0.95 |
| Aminoglycoside-Induced Damage | protects_against | phenotype | 0.95 |
| Mitochondrial Health | associated_with | phenotype | 0.95 |
| Microglial Activation | involved_in | process | 0.95 |
| Mitochondrial Homeostasis | regulates | process | 0.95 |
| Damaged Mitochondria | degrades | phenotype | 0.95 |
| cGAS-STING pathway | interacts_with | pathway | 0.95 |
| Mitochondria | targets | organelle | 0.95 |
| Triple-Negative Breast Cancer | involved_in | disease | 0.95 |
| Mitochondria | involved_in | cell_type | 0.95 |
| MITOCHONDRIA | targets | entity | 0.95 |
| MITOCHONDRIA | regulates | cell_type | 0.95 |
| Mitochondrial Quality Control | associated_with | mechanism | 0.95 |
| ALZHEIMER'S DISEASE | involved_in | disease | 0.95 |
| Cell Survival | promotes | phenotype | 0.95 |
| Mitochondrial Quality Control | contributes_to | process | 0.95 |
| Exogenous Mitochondria | degrades | process | 0.95 |
| Mitochondrial Replacement Therapy | inhibits | mechanism | 0.95 |
| Aminoglycoside-Induced Damage | inhibits | phenotype | 0.90 |
| Mitochondrial Dysfunction | protects_against | process | 0.90 |
| Mitochondrial Homeostasis | associated_with | process | 0.90 |
| Neuronal Health | involved_in | phenotype | 0.90 |
| Damaged Mitochondria Clearance | mediates | process | 0.90 |
| Age-Related Diseases | involved_in | disease | 0.90 |
| Mitochondrial Malfunction | protects_against | phenotype | 0.90 |
| NLRP3 Inflammasome | inhibits | entity | 0.90 |
| Organelle Quality Control | component_of | process | 0.90 |
| Cell Viability | protects_against | phenotype | 0.90 |
| Myocardial Ischemia/Reperfusion Injury | protects_against | disease | 0.90 |
| Autophagy | associated_with | process | 0.90 |
| Dysfunctional Mitochondria Removal | mediates | phenotype | 0.90 |
| Mitochondria | associated_with | cell_type | 0.90 |
| AGING | associated_with | phenotype | 0.90 |
| Neuronal Health | promotes | phenotype | 0.90 |
| Neuronal Survival | promotes | phenotype | 0.90 |
| MITOCHONDRIA | mediates | cell_type | 0.90 |
| Mitochondria | degrades | cell_type | 0.90 |
| Neurodegenerative Diseases | protects_against | disease | 0.90 |
| STING-Induced Inflammation | inhibits | pathway | 0.90 |
| Mitochondrial ROS | downregulates | biomarker | 0.90 |
| Renal Tubular Epithelial Cell Apoptosis | inhibits | phenotype | 0.90 |
| Renal Tubulointerstitial Fibrosis | protects_against | disease | 0.90 |
| Glucose Metabolism | associated_with | process | 0.90 |
| Age-Related Hearing Loss | implicated_in | disease | 0.90 |
| Cellular Homeostasis | involved_in | phenotype | 0.90 |
| Acute Kidney Injury | protects_against | disease | 0.88 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PARKIN | regulates | gene | 1.00 |
| PINK1 | regulates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| BNIP3 | activates | gene | 1.00 |
| PARKIN | inhibits | gene | 1.00 |
| OPTN | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| BNIP3 | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| P62 | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| MTDNA | activates | gene | 1.00 |
| MITOCHONDRIAL DNA | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| P62 | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Aging | regulates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| PRKN | regulates | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Cardiac | regulates | disease | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| NLRP3/Mitophagy Coupling Modulation | 0.522 | Neuroinflammation | Immune atlas neuroinflammation analysis |
| SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK | 0.509 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi | 0.455 | neurodegeneration | Why does PRKN-mediated mitophagy, typica |
| PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor | 0.418 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189] | ["Cho S", "Jo E", "Jang H"] | Scientific reports | 2026 | 0 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996] | Zhang HH, Zhang ZL, Xu W | Reproduction | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672] | Jiang F, Huang H, Dong Z, Zhang L, Zhang | Cell Death Discov | 2026 | 0 |
| Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824] | Zhang T, Hu L, Chen D, Chen Y, Zhou F et | Nat Commun | 2026 | 0 |
| α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317] | Wu C, Jiang J, Qiu H, Xie J, Li S | Fish Shellfish Immunol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Fang Y, Deng M, Huang K, Song H, Chu Y, | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832] | ["Tang M", "Outissint I", "Chen Y", "Gon | Journal of cellular biochemist | 2025 | 0 |
| H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alz [PMID:39862777] | Wang H, Xia H, Bai J, Wang Z, Wang Y et | J Hazard Mater | 2025 | 0 |
| The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic [PMID:40826276] | Weber ANR, McManus RM, Hornung V, Geyer | Nat Immunol | 2025 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |