Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arf5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARF5 |
| Full Name | ADP Ribosylation Factor 5 |
| Chromosome | 7q31.2 |
| Protein Family | ARF GTPase family |
| Function | is a member of the ARF family of small GTPases that play critical roles in intracellular membrane trafficking[@casler2024arftraffic]. |
| Molecular Weight | 20 kDa |
| UniProt ID | [P26447](https://www.uniprot.org/uniprot/P26447) |
| Ensembl ID | ENSG00000104081 |
| OMIM | 103185 |
| GeneCards | ARF5 |
| Human Protein Atlas | ARF5 |
| N-terminal region | Contains a myristoylation site that facilitates membrane association |
| GTP-binding domain (G-domain) | Responsible for nucleotide binding and hydrolysis |
| Switch I and Switch II regions | Conformational changes upon GTP/GDP binding that mediate interactions with effectors |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["arf5 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARF5 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARF5 | data_in | dataset_row | 0.00 |
| genes-arf5 | linked_to | wiki | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning arf5 in their description or question text
No additional research found