Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about autophagy flux: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SQSTM1 | associated_with | gene | 0.90 |
| LC3 | regulates | protein | 0.90 |
| Tetrathiomolybdate | upregulates | drug | 0.90 |
| CD36 | inhibits | protein | 0.85 |
| Lipopolysaccharide | inhibits | compound | 0.85 |
| LC3-II | biomarker_for | protein | 0.85 |
| SQSTM1 | biomarker_for | gene | 0.85 |
| p62 | biomarker_for | protein | 0.85 |
| TSPAN1 | promotes | gene | 0.80 |
| lysosomal acidification | regulates | pathway | 0.70 |
| P2Y12 inhibitors | restores | drug | 0.70 |
| advanced Alzheimer's disease | impairs | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop tACS targeting entorhinal cortex layer II SST in | 0.784 | alzheimers | Circuit-level neural dynamics in neurode |
| VCP/p97 ATPase mutations impair extraction of ubiquitinated | 0.720 | neurodegeneration | What are the neuron-specific effects of |
| NLRP3/Autophagy Flux Enhancement in Astrocytes | 0.380 | neuroinflammation | Immune atlas neuroinflammation analysis |
| Autophagy-Epigenetic Feedback Loop Creates a Compounding Bio | 0.347 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.575
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.605
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy, aging, and age-related neurodegeneration. [PMID:39406236] | Palmer JE, Wilson N, Son SM | Neuron | 2025 | 0 |
| SMAD3 and PINK1 constitute a new positive feedback loop in regulation of mitopha [PMID:40277323] | Tang M, Lu G, Shen HM | Autophagy | 2025 | 0 |
| Autophagy, aging, and age-related neurodegeneration. [PMID:39406236] | Palmer JE, Wilson N, Son SM, Obrocki P, | Neuron | 2025 | 0 |
| Autophagy-lysosomal-associated neuronal death in neurodegenerative disease. [PMID:39259382] | Nixon Ralph A | Acta neuropathologica | 2024 | 0 |
| Autophagy-lysosomal-associated neuronal death in neurodegenerative disease. [PMID:39259382] | Nixon RA | Acta neuropathologica | 2024 | 0 |
| ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind a [PMID:37127681] | Wang, Wang, Zhang, Hu, Jiang et al. | Archives of toxicology | 2023 | 0 |
| Adaptive Deep Brain Stimulation: From Experimental Evidence Toward Practical Imp [PMID:37148553] | Neumann WJ, Gilron R, Little S | Mov Disord | 2023 | 0 |
| ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind a [PMID:37127681] | Unknown | Archives of toxicology | 2023 | 0 |
| Autophagy in ovary and polycystic ovary syndrome: role, dispute and future persp [PMID:34161185] | Unknown | Autophagy | 2022 | 0 |
| The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. [PMID:33442914] | Kma, Baruah | Biotechnology and applied bioc | 2022 | 0 |
| Autophagy in ovary and polycystic ovary syndrome: role, dispute and future persp [PMID:34161185] | Kumariya, Ubba, Jha, Gayen | Autophagy | 2022 | 0 |
| The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. [PMID:33442914] | Unknown | Biotechnology and applied bioc | 2022 | 0 |
| Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular [PMID:33682185] | Song M, He J, Pan QZ | Hepatology | 2021 | 0 |
| Autophagy drives fibroblast senescence through MTORC2 regulation. [PMID:31931659] | Bernard M, Yang B, Migneault F | Autophagy | 2020 | 0 |
| ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms. [PMID:25722131] | Li L, Tan J, Miao Y, Lei P, Zhang Q | Cellular and molecular neurobi | 2015 | 0 |
| ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms. [PMID:25722131] | Li L, Tan J, Miao Y, Lei P, Zhang Q | Cellular and molecular neurobi | 2015 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.62 · 2026-04-21
closed · Rounds: 4 · Score: 0.72 · 2026-04-21
closed · Rounds: 4 · Score: 0.46 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
Hypotheses and analyses mentioning autophagy flux in their description or question text
No additional research found