entity

calcium buffering

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about calcium buffering: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

2Hypotheses

1Analyses

0Outgoing

2Incoming

6Experiments

18Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (2)

Source	Relation	Type	Str
mitochondria	mediates	cell_type	0.90
PVALB	regulates	protein	0.90

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial Calcium Buffering Enhancement via MCU Modulati	0.650	neurodegeneration	Selective vulnerability of entorhinal co
Mitochondrial Calcium Buffering Enhancement	0.000	-	Selective vulnerability of entorhinal co

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Exercise-BDNF-Mitophagy Biomarker Study in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson'	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
MLCS Quantification in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Wilson Disease Neurodegeneration: Mechanism and Therapeutic Response	clinical	Neurodegeneration	0.400	0.50	human	proposed	$7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Mitochondrial calcium uptake declines during aging and is directly activated by [PMID:39603237]	Gherardi G, Weiser A, Bermont F, Migliav	Cell Metab	2025	1
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipoly [PMID:39153480]	LaMoia TE, Hubbard BT, Guerra MT, Nasiri	Cell Metab	2024	1
Mitochondrial calcium exchange in physiology and disease. [PMID:34698550]	Garbincius JF, Elrod JW	Physiol Rev	2022	1
Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeti [PMID:41805100]	Qin D, Ding W, Wu X, Peng C, Bo Y et al.	Drug Dev Res	2026	0
Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscu [PMID:41841200]	Matias C, Snider PL, Sierra Potchanant E	J Cachexia Sarcopenia Muscle	2026	0
Zn(2+)-Dependent Modulation of the Mitochondrial Ca(2+) Uniporter Underlies Resv [PMID:41932596]	Xing B, Li X, Wang B, Huang L, Wang Q et	Exp Cell Res	2026	0
SERCA2 Dysfunction Drives Vascular Calcification via Coupling with TSPO-MCU at M [PMID:41932666]	Pi S, Liu W, Zhao J, Chen H, Luo X et al	Pharmacol Res	2026	0
Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU [PMID:39921279]	Zhao H, Chen S, Cao N, Wu W, Liu G, Gao	Advanced science (Weinheim, Ba	2025	0
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylatio [PMID:40712058]	Liu G, Zhang H, Chen S, Gao J, Zhao H, D	Cancer research	2025	0
Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567]	["Porzuczek J"]	Sensors (Basel, Switzerland)	2024	0
A vision-based real-time traffic flow monitoring system for road intersections. [PMID:36789012]	["Azimjonov J", "\u00d6zmen A", "Varan M	Multimedia tools and applicati	2023	0
Mitochondrial calcium cycling in neuronal function and neurodegeneration. [PMID:36760367]	Walters GC, Usachev YM	Frontiers in cell and developm	2023	0
The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human [PMID:37759703]	D'Angelo D, Rizzuto R	Biomolecules	2023	0
The Importance of Emotional Intelligence in University Athletes: Analysis of Its [PMID:36901234]	["Mercader-Rubio I", "\u00c1ngel N"]	International journal of envir	2023	0
Synergistic Antitumoral Effect of Epigenetic Inhibitors and Gemcitabine in Pancr [PMID:35890123]	["Maietta I", "Mart\u00ednez-P\u00e9rez	Pharmaceuticals (Basel, Switze	2022	0
The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liabi [PMID:34789012]	["Mahjani B", "Klei L", "Mattheisen M",	The American journal of psychi	2022	0
Controlled synthesis of silver-based ternary quantum dots with outstanding lumin [PMID:35678901]	["Mbaz G", "Parani S", "Oluwafemi O"]	Journal of fluorescence	2022	0
Multiple Primary Malignancies in Head and Neck Cancer: A University Hospital Exp [PMID:34567890]	["Batista MV", "Ulrich J", "Costa L", "R	Cureus	2021	0
Early treatment with sumatriptan prevents PACAP38-induced migraine: A randomised [PMID:33567890]	["Wienholtz N", "Christensen C", "Zhang	Cephalalgia : an international	2021	0
Severe vernal keratoconjunctivitis complicated by anaesthetic abuse [PMID:32456789]	Anchouche Sonia; Yin Jia	Canadian Journal of Ophthalmol	2020	0