organelle

mitochondria

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about mitochondria: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4259Connections

30Hypotheses

19Analyses

13Outgoing

26Incoming

Summary

mitochondria is an entity related to neurodegeneration research. Key relationships include: regulates, accumulates in, accumulates. Connected to 16 entities in the SciDEX knowledge graph.

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Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    MITOCHONDRIA(["MITOCHONDRIA"])
    NEUROINFLAMMATION(["NEUROINFLAMMATION"])
    Ischemia["Ischemia"]
    Mtor["Mtor"]
    Autophagy["Autophagy"]
    Aging["Aging"]
    Parkinson["Parkinson"]
    Alzheimer["Alzheimer"]
    Tumor["Tumor"]
    Cancer["Cancer"]
    Apoptosis["Apoptosis"]
    Neurodegeneration["Neurodegeneration"]
    PARKIN(["PARKIN"])
    Mitophagy["Mitophagy"]

    MITOCHONDRIA -->|"associated with"| NEUROINFLAMMATION
    MITOCHONDRIA -->|"activates"| Ischemia
    MITOCHONDRIA -->|"activates"| Mtor
    MITOCHONDRIA -->|"activates"| Autophagy
    MITOCHONDRIA -->|"interacts with"| Autophagy
    MITOCHONDRIA -->|"activates"| Aging
    MITOCHONDRIA -->|"regulates"| Parkinson
    MITOCHONDRIA -->|"regulates"| Alzheimer
    MITOCHONDRIA -->|"activates"| Tumor
    MITOCHONDRIA -->|"activates"| Cancer
    MITOCHONDRIA -->|"activates"| Apoptosis
    MITOCHONDRIA -->|"contributes to"| Neurodegeneration
    MITOCHONDRIA -->|"contributes to"| Autophagy
    MITOCHONDRIA -->|"regulates"| PARKIN
    MITOCHONDRIA -->|"regulates"| Mitophagy

    style MITOCHONDRIA fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (2700)

Target	Relation	Type	Str
ATP production	mediates	process	0.95
calcium buffering	mediates	process	0.90
apoptosis	regulates	phenotype	0.80
DNA	produces	protein	0.80
autophagy	regulates	process	0.70
mitophagy	interacts_with	process	0.70
endoplasmic reticulum	interacts_with	entity	0.70
oligodendrocyte	co_discussed	concept	0.65
myelin	co_discussed	concept	0.65
calcium	regulates	protein	0.64
PRKN	loss_affects	entity	0.60
tau	loss_affects	entity	0.60
synapse	loss_affects	entity	0.60

Incoming (1559)

Source	Relation	Type	Str
PARKIN	modifies	protein	0.90
KIF5A	interacts_with	protein	0.90
phosphatidylethanolamine biosynthesis	expressed_in	pathway	0.90
TRAK1	binds	protein	0.90
TRAK2	binds	protein	0.90
autophagy	inhibits	process	0.70
OPTN	expressed_in	protein	0.70
PINK1	regulates	protein	0.70
Parkin	regulates	protein	0.70
PINK1	accumulates	protein	0.70
PARKIN	accumulates	protein	0.70
PINK1	accumulates_in	protein	0.70
PARKIN	accumulates_in	protein	0.70
SIRT3	regulates	gene	0.70
autophagy	regulates	process	0.70
proinflammatory cytokines	modulates	protein	0.70
alpha-synuclein	co_discussed	concept	0.65
SYP	co_discussed	gene	0.65
TFEB	co_discussed	gene	0.65
CDK5	co_discussed	gene	0.65
FOXO3A	regulates	protein	0.64
TRAK1	interacts_with	protein	0.60
LRP1	inhibits	entity	0.60
tau	activates	entity	0.60
LRRK2	loss_affects	entity	0.60
SOD1	loss_affects	entity	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.582	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.580	neurodegeneration	What are the mechanisms by which gut mic
AMPK hypersensitivity in astrocytes creates enhanced mitocho	0.570	neurodegeneration	Mitochondrial transfer between astrocyte
Senescent Cell Mitochondrial DNA Release	0.545	neurodegeneration	Senolytic therapy for age-related neurod
Near-infrared light therapy stimulates COX4-dependent mitoch	0.514	neurodegeneration	Mitochondrial transfer between astrocyte

SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.509	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
CRISPR-Mediated Mitochondrial Genome Editing for Complex I D	0.491	neurodegeneration	CRISPR-based therapeutic approaches for
TFAM overexpression creates mitochondrial donor-recipient gr	0.474	neurodegeneration	Mitochondrial transfer between astrocyte
C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction v	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective	0.450	neurodegeneration	Mitochondrial transfer between neurons a
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration	0.448	neurodegeneration	Epigenetic reprogramming in aging neuron
Ancestry-Adapted Mitochondrial Rescue Therapy	0.448	neurodegeneration	How do neurodegeneration gene expression
Mitochondrial-Cytokine Axis Modulation	0.443	neurodegeneration	Gene expression changes in aging mouse b
Mitochondrial Transfer Pathway Enhancement	0.443	neurodegeneration	Astrocyte reactivity subtypes in neurode
Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur	0.435	translational neuroscience	Which metabolic biomarkers can distingui
Mitochondrial-Lysosomal Contact Site Engineering	0.430	neurodegeneration	Autophagy-lysosome pathway convergence a
Mitochondrial NAD+ Salvage Enhancement	0.426	neurodegeneration	Gene expression changes in aging mouse b
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy	0.426	neurodegeneration	Mitochondrial transfer between neurons a
Mitochondrial-Lysosomal Coupling Enhancer	0.422	neurodegeneration	Does TFEB dysfunction cause neurodegener
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor	0.418	neurodegeneration	Mitochondrial transfer between neurons a
CX43 hemichannel engineering enables size-selective mitochon	0.415	neurodegeneration	Mitochondrial transfer between astrocyte
RAB27A-dependent extracellular vesicle engineering for mitoc	0.414	neurodegeneration	Mitochondrial transfer between astrocyte
Mitochondrial RNA Granule Rescue Pathway	0.400	neurodegeneration	RNA binding protein dysregulation across
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction	0.398	neurodegeneration	Metabolic reprogramming in neurodegenera
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling	0.398	neurodegeneration	Gene expression changes in aging mouse b
Gap Junction Hemichannel Modulation for Controlled Mitochond	0.386	neurodegeneration	Mitochondrial transfer between neurons a
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption	0.384	neurodegeneration	Protein aggregation cross-seeding across
Mitochondrial SPM Synthesis Platform Engineering	0.383	neurodegeneration	Neuroinflammation resolution mechanisms
GAP43-mediated tunneling nanotube stabilization enhances neu	0.380	neurodegeneration	Mitochondrial transfer between astrocyte
Optogenetic Control of Mitochondrial Transfer Networks	0.378	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (19)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673]	Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge	Autophagy	2024	1
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142]	Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha	Nat Cell Biol	2024	1
NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. [PMID:37683629]	Zhan R, Meng X, Tian D, Xu J, Cui H, Yan	Neuron	2023	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096]	Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li	Autophagy	2023	1
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090]	Lin MM, Liu N, Qin ZH, Wang Y	Acta Pharmacol Sin	2022	1
Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470]	Boal AM, Risner ML, Cooper ML, Wareham L	Cells	2021	1
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785]	Zhao M, Wang Y, Li L, Liu S, Wang C, Yua	Theranostics	2021	1
Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045]	Filograna R, Mennuni M, Alsina D, Larsso	FEBS Lett	2021	1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434]	Li C, Zhang Y, Liu J, Kang R, Klionsky D	Autophagy	2021	1
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. [PMID:32722981]	Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W	Autophagy	2021	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuro [PMID:26121488]	Hang L, Thundyil J, Lim KL	Ann N Y Acad Sci	2015	1
SIRT5 regulation of ammonia-induced autophagy and mitophagy. [PMID:25700560]	Polletta L, Vernucci E, Carnevale I, Arc	Autophagy	2015	1
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855]	["Ying H", "Fan H", "Wang Y", "Jiang R",	Advanced science (Weinheim, Ba	2026	0
Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580]	Wen Y, Yuan Y, Zhang H, Liu Y	Molecular medicine reports	2026	0
Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609]	Yakati V, Rao SS	Biotechnol Bioeng	2026	0

mitochondria

Understanding Entity Pages

Summary

Wiki Pages (21)

Mitochondria

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Pathway Diagram

Outgoing (2700)

Incoming (1559)

Targeting Hypotheses (30)

Mentioning Analyses (19)

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

What are the molecular determinants that control directional mitochondrial trans

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Do transferred mitochondria from diseased astrocytes carry pathological damage t

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Epigenetic reprogramming in aging neurons

Quantitative proteomics of the aging synapse in early Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

Mitochondrial transfer between astrocytes and neurons

Mitochondrial transfer between neurons and glia

Mitochondrial transfer between neurons and glia

Mitochondrial transfer between astrocytes and neurons

Related Papers (20)

mitochondria

Understanding Entity Pages

Summary

Wiki Pages (21)

Mitochondria

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

nimodipine-als

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

NRF2 Oxidative Stress Pathway

coq10-neurodegeneration

NTF4 Protein

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

ALS Failed Approaches Analysis

Pathway Diagram

Outgoing (2700)

Incoming (1559)

Targeting Hypotheses (30)

Mentioning Analyses (19)

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

What are the molecular determinants that control directional mitochondrial trans

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Do transferred mitochondria from diseased astrocytes carry pathological damage t

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Epigenetic reprogramming in aging neurons

Quantitative proteomics of the aging synapse in early Alzheimer disease

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

Mitochondrial transfer between astrocytes and neurons

Mitochondrial transfer between neurons and glia

Mitochondrial transfer between neurons and glia

Mitochondrial transfer between astrocytes and neurons

Related Papers (20)