Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about circadian gene expression: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CLOCK | involved_in | gene | 0.90 |
| BMAL1 | involved_in | gene | 0.90 |
| PER | involved_in | gene | 0.90 |
| CRY | involved_in | gene | 0.90 |
| CLOCK | regulates | gene | 0.70 |
| BMAL1 | regulates | gene | 0.70 |
| BMAL1 hypermethylation | disrupts | mechanism | 0.70 |
| HDAC3 inhibition | restores | drug | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.643
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.763
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.68 · 2026-04-21
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
Hypotheses and analyses mentioning circadian gene expression in their description or question text
No additional research found