concept

PER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1149Connections

22Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

PER is a concept in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, Aging, Als. Connected to 640 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	PER
Category	polly, data-harmonization, metadata-extraction, knowledge-graph
Key Genes/Proteins	DNA
Related Diseases	Als, Cancer, Neurodegeneration, Stroke
Related Pathways	Oxidative Stress
Linked Hypotheses	29 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    PER["PER"]
    PER -->|"interacts"| CRY["CRY"]
    PER -->|"regulates"| Als["Als"]
    PER -->|"regulates"| Alzheimer["Alzheimer"]
    PER -->|"regulates"| Diabetes["Diabetes"]
    PER -->|"regulates"| Inflammation["Inflammation"]
    PER -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    PER -->|"regulates"| Obesity["Obesity"]
    PER -->|"regulates"| Parkinson["Parkinson"]
    BMAL1["BMAL1"] -->|"regulates"| PER
    CLOCK["CLOCK"] -->|"regulates"| PER
    ARNT["ARNT"] -->|"expressed in"| PER
    CRY -->|"expressed in"| PER
    CNO["CNO"] -->|"regulates"| PER
    MTDNA["MTDNA"] -->|"expressed in"| PER

Outgoing (788)

Target	Relation	Type	Str
Als	associated_with	disease	1.00
Als	activates	disease	1.00
Cancer	expressed_in	disease	1.00
Neurodegeneration	associated_with	disease	0.95
Cancer	associated_with	disease	0.95
Stroke	associated_with	disease	0.95
Als	expressed_in	disease	0.95
METABOLIC HEALTH	regulates	entity	0.95
circadian rhythm	drives	process	0.95
Circadian Rhythms	involved_in	process	0.90
Cellular Metabolism	regulates	process	0.90
Circadian Gene Expression	involved_in	process	0.90
Circadian Rhythm Regulation	regulates	process	0.90
DNA	associated_with	gene	0.90
Oxidative Stress	activates	pathway	0.90
Alzheimer	associated_with	disease	0.85
Diabetes	associated_with	disease	0.85
Als	therapeutic_target	disease	0.85
Cancer	therapeutic_target	disease	0.85
Tumor	therapeutic_target	disease	0.85
Aging	associated_with	disease	0.85
Alzheimer	activates	disease	0.85
Inflammation	associated_with	disease	0.85
Als	inhibits	disease	0.85
LIPID METABOLISM	regulates	entity	0.85
SLEEP-WAKE CYCLE	regulates	entity	0.85
CRY	interacts_with	protein	0.80
Insomnia	associated_with	disease	0.80
circadian rhythm	participates_in	biological_process	0.80
Metabolism	regulates	biological_process	0.80
Circadian Rhythm	involved_in	process	0.80
Inflammation	regulates	disease	0.75
Neuroinflammation	regulates	disease	0.75
Cardiovascular	associated_with	disease	0.75
Dementia	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Carcinoma	associated_with	disease	0.75
Tumor	associated_with	disease	0.75
Amyotrophic Lateral Sclerosis	associated_with	disease	0.75
Aging	activates	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Als	protects_against	disease	0.75
Atherosclerosis	associated_with	disease	0.75
Alzheimer	biomarker_for	disease	0.75
Inflammation	biomarker_for	disease	0.75
Als	causes	disease	0.75
Parkinson	activates	disease	0.75
Inflammation	activates	disease	0.75
Parkinson	associated_with	disease	0.75

Incoming (361)

Source	Relation	Type	Str
CANCER	expressed_in	gene	1.00
GENES	associated_with	gene	0.90
CANCER	associated_with	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
OBSTRUCTIVE SLEEP APNEA SYNDROME	modulates	entity	0.85
ALZHEIMER	associated_with	gene	0.80
DNA	associated_with	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
STROKE	associated_with	gene	0.80
Obstructive Sleep Apnea Syndrome	modulates	disease	0.75
OSAS	modulates	disease	0.75
MITOCHONDRIAL DNA	associated_with	gene	0.70
GENES	expressed_in	gene	0.70
MOTOR NEURONS	associated_with	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
NEURODEGENERATIVE DISEASES	regulates	gene	0.70
ALZHEIMER	biomarker_for	gene	0.70
DNA	expressed_in	gene	0.70
CANCER	activates	gene	0.70
PI3K	activates	gene	0.70
CANCER	regulates	gene	0.70
CANCER	therapeutic_target	gene	0.70
TP53	expressed_in	gene	0.70
GENES	causes	gene	0.70
PARKINSON	activates	gene	0.70
CREB	activates	gene	0.70
ALZHEIMER	activates	gene	0.70
PARKINSON	associated_with	gene	0.70
GENES	therapeutic_target	gene	0.70
NF-ΚB	activates	gene	0.70
STAT3	activates	gene	0.70
ERK	activates	gene	0.70
INFLAMMATION	associated_with	gene	0.70
BMAL1	associated_with	gene	0.60
CLOCK	associated_with	gene	0.60
CRY	associated_with	gene	0.60
BMAL1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
ARNT	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
CRY	expressed_in	gene	0.60
ABCB1	associated_with	gene	0.60
CNO	regulates	gene	0.60
MAX	associated_with	gene	0.60
MTDNA	expressed_in	gene	0.60
OVERVIEW	associated_with	gene	0.60
AHR	associated_with	gene	0.60
FGFR3	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60

Targeting Hypotheses (22)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis	0.606	neurodegeneration	How does FUS loss-of-function in TAZ reg
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra

Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
AMPK hypersensitivity in astrocytes creates enhanced mitocho	0.570	neurodegeneration	Mitochondrial transfer between astrocyte
APOE4 Allosteric Rescue via Small Molecule Chaperones	0.542	neurodegeneration	APOE4 structural biology and therapeutic
Senescence-Induced Lipid Peroxidation Spreading	0.533	neurodegeneration	Senolytic therapy for age-related neurod
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.527	neuroscience	Circuit-level neural dynamics in neurode
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.520	neurodegeneration	How do the seven novel ALS genes functio
Proteostasis Enhancement via APOE Chaperone Targeting	0.496	neurodegeneration	Mechanistic role of APOE in neurodegener
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Gut Barrier Permeability-α-Synuclein Axis Modulation	0.487	neurodegeneration	What are the mechanisms by which gut mic
Perforant Path Presynaptic Terminal Protection Strategy	0.484	neurodegeneration	Selective vulnerability of entorhinal co
Microglial Efferocytosis Enhancement via GPR32 Superagonists	0.483	neurodegeneration	Neuroinflammation resolution mechanisms
Chaperone-Mediated APOE4 Refolding Enhancement	0.482	neurodegeneration	APOE4 structural biology and therapeutic
Peripheral-Central Immune Decoupling Therapy	0.462	-	Neuroinflammation and microglial priming
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.443	neurodegeneration	Perivascular spaces and glymphatic clear
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.420	neurodegeneration	Protein aggregation cross-seeding across
Perinatal Immune Challenge Prevention	0.416	neurodegeneration	Neuroinflammation and microglial priming
Perinatal Hypoxia-Primed Microglia Targeting	0.385	Alzheimer's disease	Neuroinflammation and microglial priming

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591]	Rusmini P, Cortese K, Crippa V, Cristofa	Autophagy	2019	2
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759]	Mao P, Wang Z, Duan J, Dong P, Yuan C, L	J Agric Food Chem	2025	1
Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591]	Luo Y, Long M, Wu X, Zeng L	Front Immunol	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685]	Litvinchuk A, Suh JH, Guo JL, Lin K, Dav	Neuron	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283]	Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh	Biochem Pharmacol	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuro [PMID:26121488]	Hang L, Thundyil J, Lim KL	Ann N Y Acad Sci	2015	1
AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cel [PMID:41694579]	Zhu L, Wang Y, Shi X, Yu M, Cai X, Chen	International journal of biolo	2026	0
Single-cell transcriptome analysis reveals a cellular immune response in common [PMID:41692207]	Shi X, Ji G, Liu D, Zhao T, Tian S, Li S	International journal of biolo	2026	0
Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: [PMID:41702183]	Li Y, Feng X, Zheng L	Tissue & cell	2026	0
Integration proteomics analysis to identify AMPK as key target pathways of TCM f [PMID:41788172]	Chen YJ, Ning DS, Wang CC, Zhao HW, Wang	Journal of traditional and com	2026	0
Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoart [PMID:41791307]	Zhai Y, Zhou P, Dan L, Ma M, Liu B, Zhan	International immunopharmacolo	2026	0

PER

Understanding Entity Pages

Summary

Wiki Pages (21)

Elucidata Polly (Multi-Omics Data Platform)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

primary-progressive-aphasia

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

PI-2620 Tau PET in PSP

Pathway Diagram

Outgoing (788)

Incoming (361)

Targeting Hypotheses (22)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

What upstream mechanisms trigger p53 activation specifically in response to poly

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

How does pericyte senescence mechanistically promote glioma cell growth and inva

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What are the specific circulating factors in exercise-conditioned plasma that me

What genetic risk factors predispose individuals to developing CTE following rep

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How does APOE4's beneficial immune function reconcile with its established role

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

What molecular mechanisms enable functional recovery and muscle re-innervation a

Related Papers (20)